Details of the Drug Combination

General Information of Drug Combination (ID: DC8YVY0)

Drug Combination Name
Droxidopa Carbidopa
Indication
Disease Entry Status REF
Parkinson Disease Phase 1 [1]
Component Drugs Droxidopa   DM5YF4M Carbidopa   DMHRG8Q
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Droxidopa
Disease Entry ICD 11 Status REF
Chronic fatigue syndrome 8E49 Approved [2]
Neurogenic orthostatic hypotension 8D87.0Y Approved [3]
Pure autonomic failure N.A. Approved [2]
Droxidopa Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
DOPA decarboxylase (DDC) DETK9CN DDC_HUMAN Metabolism [6]
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Indication(s) of Carbidopa
Disease Entry ICD 11 Status REF
Parkinson disease 8A00.0 Approved [4]
Parkinsonian disorder N.A. Approved [5]
Postencephalitic Parkinson disease N.A. Approved [5]
Carbidopa Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aromatic-L-amino-acid decarboxylase (DDC) TTN451K DDC_HUMAN Inhibitor [7]
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Carbidopa Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Increases Methylation [8]
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References

1 ClinicalTrials.gov (NCT00547911) Augmenting Effects of L-DOPS With Carbidopa and Entacapone
2 Droxidopa FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7391).
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5159).
5 Carbidopa FDA Label
6 L-Dihydroxyphenylserine (L-DOPS): a norepinephrine prodrug. Cardiovasc Drug Rev. 2006 Fall-Winter;24(3-4):189-203.
7 Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease. Semin Neurol. 2001;21(1):15-22.
8 Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. Mol Pharmacol. 2001 Feb;59(2):393-402. doi: 10.1124/mol.59.2.393.