Details of the Drug Combination

General Information of Drug Combination (ID: DC90236)

Drug Combination Name

Ranolazine

Indication

Disease Entry	Status	REF
Type 2 Diabetes Mellitus	Phase 1	[1]

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Ranolazine

Disease Entry	ICD 11	Status	REF
Acute coronary syndrome	BA41	Approved	[2]
Angina pectoris	BA40	Approved	[2]
Chronic/stable angina	BA40.1	Approved	[3]
Diarrhea-predominant irritable bowel syndrome	DD91.01	Approved	[2]
Paroxysmal atrial fibrillation	BC81.30	Phase 2	[4]

Ranolazine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Plasminogen (PLG)	TTP86E2	PLMN_HUMAN	Modulator	[5]
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Ranolazine Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]
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Ranolazine Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[7]
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References

1	ClinicalTrials.gov (NCT01546558) Single Cohort, 2-Period Study to Assess Pharmacokinetics of Metformin Alone and in Combination With Ranolazine 500 mg
2	Ranolazine FDA Label
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7291).
4	Clinical pipeline report, company report or official report of Gilead.
5	Tranexamic acid in trauma: how should we use it. J Trauma Acute Care Surg. 2013 Jun;74(6):1575-86.
6	Ranolazine-tacrolimus interaction. Ann Pharmacother. 2010 Nov;44(11):1844-9.
7	Ranolazine: a contemporary review. J Am Heart Assoc. 2016 Mar 15;5(3):e003196.