Details of the Drug Combination

General Information of Drug Combination (ID: DCBKGCV)

• Drug Combination Name: Dexrazoxane + Plicamycin
• Indication: High grade ovarian serous adenocarcinoma; Status: Investigative [1]
• Component Drugs:
  Dexrazoxane (DMD7X1O): Small molecular drug
  Plicamycin (DM7C8YV): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: OVCAR-5
  Zero Interaction Potency (ZIP) Score: 0.01
  Bliss Independence Score: 6.18
  Loewe Additivity Score: 6.27
  LHighest Single Agent (HSA) Score: 6.13

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Dexrazoxane

Disease Entry	ICD 11	Status	REF
Breast cancer	2C60-2C65	Approved	[2]
Chemoprotection	N.A.	Approved	[3]
Inflammatory breast cancer	2C62	Approved	[4]
Respiratory tract disease	CB7Z	Investigative	[5]

Dexrazoxane Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase II beta (TOP2B)	TT4NVEM	TOP2B_HUMAN	Inhibitor	[8]
DNA topoisomerase II (TOP2)	TT0IHXV	TOP2A_HUMAN; TOP2B_HUMAN	Modulator	[9]

Dexrazoxane Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Dihydropyrimidinase-related protein 1 (DRP1)	DE0EUXB	DPYL1_HUMAN	Metabolism	[10]

Dexrazoxane Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Activity	[11]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[3]
Testicular cancer	2C80	Approved	[3]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[6]
Lung cancer	2C25.0	Investigative	[7]
Ovarian cancer	2C73	Investigative	[7]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[13]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[14]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[15]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[15]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[15]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[16]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[16]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[17]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[12]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[18]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[19]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[20]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[12]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[21]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[18]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[22]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[23]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCIFVCJ	HL-60(TB)	Investigative	[24]
Adult T acute lymphoblastic leukemia	DC1CXSU	MOLT-4	Investigative	[24]
Anaplastic large cell lymphoma	DCSZUSY	SR	Investigative	[24]
Childhood T acute lymphoblastic leukemia	DC3V7JA	CCRF-CEM	Investigative	[24]
Chronic myelogenous leukemia	DC6W5PQ	K-562	Investigative	[24]
Clear cell renal cell carcinoma	DCMA5UE	A498	Investigative	[24]
Glioma	DCIADZ5	SF-539	Investigative	[24]
Plasma cell myeloma	DCI81IH	RPMI-8226	Investigative	[24]
Carcinoma	DCAFZRW	RXF 393	Investigative	[25]
Colon adenocarcinoma	DCQQ6D4	COLO 205	Investigative	[25]
Colon carcinoma	DCE6P1Q	KM12	Investigative	[25]
Invasive ductal carcinoma	DCMDXSC	BT-549	Investigative	[25]
Invasive ductal carcinoma	DCZE2RW	T-47D	Investigative	[25]
Invasive ductal carcinoma	DCZBKKJ	HS 578T	Investigative	[25]
Adenocarcinoma	DCPYEDW	SW-620	Investigative	[1]
Adenocarcinoma	DC9GSPC	HCT116	Investigative	[1]
Large cell lung carcinoma	DCR9ZVA	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DC2WA1C	NCI-H522	Investigative	[1]
Melanoma	DCO661E	MALME-3M	Investigative	[1]

References

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• [4] Dexrazoxane FDA Label
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