Details of the Drug Combination

General Information of Drug Combination (ID: DCCCO03)

Drug Combination Name
T-3.5 MK-4815
Indication
Disease Entry Status REF
DD2 Investigative [1]
Component Drugs T-3.5   DM3Q1HL MK-4815   DMT9K74
N.A. N.A.
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DD2
Zero Interaction Potency (ZIP) Score: 5.646
Bliss Independence Score: 12.168
Loewe Additivity Score: 2.853
LHighest Single Agent (HSA) Score: 4.511

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Hepatoblastoma DC39677 HB3 Investigative [3]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.