Details of the Drug Combination

General Information of Drug Combination (ID: DCCCO03)

Drug Combination Name

T-3.5 MK-4815

Indication

Disease Entry	Status	REF
DD2	Investigative	[1]

Component Drugs

T-3.5 DM3Q1HL

MK-4815 DMT9K74

N.A.

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: DD2

Zero Interaction Potency (ZIP) Score: 5.646

Bliss Independence Score: 12.168

Loewe Additivity Score: 2.853

LHighest Single Agent (HSA) Score: 4.511

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Hepatoblastoma	DC39677	HB3	Investigative	[3]
------------------------------------------------------------------------------------

References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976