Details of the Drug Combination

General Information of Drug Combination (ID: DCDNBV8)

Drug Combination Name
AKB-6548 Rifampicin
Indication
Disease Entry Status REF
Drug Interaction Potentiation Phase 1 [1]
Component Drugs AKB-6548   DM2EJM3 Rifampicin   DM5DSFZ
N.A. N.A.
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of AKB-6548
Disease Entry ICD 11 Status REF
Anaemia 3A90 Phase 3 [2]
AKB-6548 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HIF-prolyl hydroxylase (HPH) TTJQFBG NOUNIPROTAC Modulator [5]
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Indication(s) of Rifampicin
Disease Entry ICD 11 Status REF
Non-insulin dependent diabetes 5A11 Approved [3]
Pulmonary tuberculosis 1B10.Z Approved [4]
Rifampicin Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [14]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [15]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [16]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Metabolism [17]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [18]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [19]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [20]
Rifampicin monooxygenase (rox) DE6PKFB ROX_NOCFA Metabolism [21]
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⏷ Show the Full List of 8 DME(s)
Rifampicin Interacts with 159 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Expression [22]
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Increases Expression [23]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Increases Expression [24]
Cocaine esterase (CES2) OTC647SQ EST2_HUMAN Increases Expression [25]
Sterol 26-hydroxylase, mitochondrial (CYP27A1) OT649C01 CP27A_HUMAN Increases Expression [26]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Increases Expression [27]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Expression [28]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1) OTQY6ZSF HEM1_HUMAN Increases Expression [29]
Transmembrane protein 120B (TMEM120B) OTA5XMI9 T120B_HUMAN Decreases Expression [8]
Uncharacterized protein C4orf51 (C4ORF51) OTIHD7NB CD051_HUMAN Decreases Expression [8]
Ankyrin repeat domain-containing protein 65 (ANKRD65) OTSZCFD8 ANR65_HUMAN Decreases Expression [8]
Transcription factor EC (TFEC) OTUST8MR TFEC_HUMAN Increases Expression [8]
Obscurin-like protein 1 (OBSL1) OT6M8M3J OBSL1_HUMAN Decreases Expression [8]
SUN domain-containing protein 1 (SUN1) OTIU8V4U SUN1_HUMAN Decreases Expression [8]
Integrin beta-like protein 1 (ITGBL1) OTJDHE17 ITGBL_HUMAN Decreases Expression [8]
Coagulation factor XIII B chain (F13B) OTIZXROK F13B_HUMAN Increases Expression [8]
Myocardial zonula adherens protein (MYZAP) OTAZCNBT MYZAP_HUMAN Decreases Expression [8]
LIM and senescent cell antigen-like-containing domain protein 3 (LIMS3) OTTMS7V8 LIMS3_HUMAN Decreases Expression [8]
Spectrin beta chain, erythrocytic (SPTB) OT1Q9ABM SPTB1_HUMAN Increases Expression [8]
Myosin-6 (MYH6) OT3YNCH1 MYH6_HUMAN Increases Expression [8]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Decreases Expression [8]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) OTODG57A FUT1_HUMAN Decreases Expression [8]
Nuclear transcription factor Y subunit alpha (NFYA) OTWFFOVH NFYA_HUMAN Decreases Expression [8]
Paired box protein Pax-7 (PAX7) OTDMQRPO PAX7_HUMAN Decreases Expression [8]
Adenosine receptor A2a (ADORA2A) OTVRBZ0I AA2AR_HUMAN Decreases Expression [8]
Leukocyte tyrosine kinase receptor (LTK) OT4GPX7K LTK_HUMAN Increases Expression [8]
Guanine nucleotide-binding protein G(olf) subunit alpha (GNAL) OTESDTEU GNAL_HUMAN Decreases Expression [8]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Increases Expression [8]
Dual specificity protein kinase CLK2 (CLK2) OT1CRSY2 CLK2_HUMAN Decreases Expression [8]
Type I iodothyronine deiodinase (DIO1) OTFYLYJ0 IOD1_HUMAN Increases Expression [8]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Increases Expression [8]
Neural retina-specific leucine zipper protein (NRL) OT65MFKQ NRL_HUMAN Increases Expression [8]
Aquaporin-4 (AQP4) OTA9MYD5 AQP4_HUMAN Decreases Expression [8]
High mobility group nucleosome-binding domain-containing protein 5 (HMGN5) OTUUAHVQ HMGN5_HUMAN Increases Expression [8]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Decreases Expression [8]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Expression [8]
28 kDa heat- and acid-stable phosphoprotein (PDAP1) OTJSWMOD HAP28_HUMAN Decreases Expression [8]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Increases Expression [8]
Mediator of RNA polymerase II transcription subunit 1 (MED1) OTOO24C4 MED1_HUMAN Decreases Expression [8]
INO80 complex subunit D (INO80D) OTY39R4P IN80D_HUMAN Decreases Expression [8]
Arylsulfatase J (ARSJ) OTE0YXM1 ARSJ_HUMAN Decreases Expression [8]
Uncharacterized protein C9orf153 (C9ORF153) OT4GKX8W CI153_HUMAN Decreases Expression [8]
Ras-related GTP-binding protein B (RRAGB) OTY10XRU RRAGB_HUMAN Decreases Expression [8]
Olfactory receptor 4A47 (OR4A47) OTB5Y637 O4A47_HUMAN Decreases Expression [8]
NADH-cytochrome b5 reductase-like (CYB5RL) OTPPN39P NB5R5_HUMAN Increases Expression [8]
Transmembrane protein 88 (TMEM88) OTA96YEL TMM88_HUMAN Increases Expression [8]
Thrombospondin type-1 domain-containing protein 4 (THSD4) OTXDBMDC THSD4_HUMAN Increases Expression [8]
Ankyrin repeat and sterile alpha motif domain-containing protein 1B (ANKS1B) OT26DGM9 ANS1B_HUMAN Decreases Expression [8]
Exopolyphosphatase PRUNE1 (PRUNE1) OTQ3UHWQ PRUN1_HUMAN Decreases Expression [8]
General transcription factor II-I repeat domain-containing protein 2A (GTF2IRD2) OT63Q58O GTD2A_HUMAN Increases Expression [8]
Dynein regulatory complex protein 11 (IQCA1) OTFBF3FI DRC11_HUMAN Decreases Expression [8]
Kin of IRRE-like protein 3 (KIRREL3) OTW7PENS KIRR3_HUMAN Decreases Expression [8]
Kelch-like protein 23 (KLHL23) OT2UVSD2 KLH23_HUMAN Decreases Expression [8]
Transmembrane protein 145 (TMEM145) OT62OZHH TM145_HUMAN Increases Expression [8]
Ethanolamine-phosphate phospho-lyase (ETNPPL) OTSXO9P6 AT2L1_HUMAN Increases Expression [8]
Probable mitochondrial glutathione transporter SLC25A40 (SLC25A40) OTYMJ69D S2540_HUMAN Decreases Expression [8]
Protein FAM200A (FAM200A) OTB1SATW F200A_HUMAN Increases Expression [8]
Tsukushi (TSKU) OT1XMRIM TSK_HUMAN Increases Expression [8]
Septin-8 (SEPTIN8) OTSZLI64 SEPT8_HUMAN Increases Expression [8]
Homeobox protein DLX-4 (DLX4) OTLWVCN4 DLX4_HUMAN Decreases Expression [8]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Decreases Expression [8]
DDB1- and CUL4-associated factor 5 (DCAF5) OTTUFC93 DCAF5_HUMAN Decreases Expression [8]
Protein TBATA (TBATA) OTGDMAAL TBATA_HUMAN Decreases Expression [8]
Nucleosome assembly protein 1-like 5 (NAP1L5) OTF4Q6ZW NP1L5_HUMAN Increases Expression [8]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2) OTEYO9TM AGAP2_HUMAN Decreases Expression [8]
Interleukin-12 receptor subunit beta-2 (IL12RB2) OTDLV8H8 I12R2_HUMAN Decreases Expression [8]
RANBP2-like and GRIP domain-containing protein 5/6 (RGPD6) OT1KQSOB RGPD5_HUMAN Decreases Expression [8]
Tripartite motif-containing protein 51 (TRIM51) OT5Y1T5Q TRI51_HUMAN Decreases Expression [8]
Sorbin and SH3 domain-containing protein 1 (SORBS1) OTWH8762 SRBS1_HUMAN Decreases Expression [8]
Zinc finger protein GLIS2 (GLIS2) OTOUUV1X GLIS2_HUMAN Increases Expression [8]
Paternally-expressed gene 3 protein (PEG3) OTHQW98S PEG3_HUMAN Increases Expression [8]
Serine/threonine-protein kinase SIK2 (SIK2) OTODY7XG SIK2_HUMAN Decreases Expression [8]
5' exonuclease Apollo (DCLRE1B) OT2LFW7A DCR1B_HUMAN Decreases Expression [8]
Sideroflexin-1 (SFXN1) OTL66767 SFXN1_HUMAN Decreases Expression [8]
Casein kinase I isoform gamma-1 (CSNK1G1) OTCXB7BI KC1G1_HUMAN Decreases Expression [8]
Phospholipase A and acyltransferase 2 (PLAAT2) OTI5RMWB PLAT2_HUMAN Decreases Expression [8]
Centlein (CNTLN) OT13NATW CNTLN_HUMAN Increases Expression [8]
Actin-related protein 10 (ACTR10) OTRF3E58 ARP10_HUMAN Increases Expression [8]
Polycystin-2-like protein 1 (PKD2L1) OT1KJDAT PK2L1_HUMAN Decreases Expression [8]
ABI gene family member 3 (ABI3) OTQTDSHP ABI3_HUMAN Decreases Expression [8]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Increases Expression [8]
STE20/SPS1-related proline-alanine-rich protein kinase (STK39) OTXHT5FR STK39_HUMAN Increases Expression [8]
Paired immunoglobulin-like type 2 receptor alpha (PILRA) OTBE0PLF PILRA_HUMAN Decreases Expression [8]
Integrator complex subunit 6 (INTS6) OT6GDV46 INT6_HUMAN Decreases Expression [8]
Cip1-interacting zinc finger protein (CIZ1) OT3UKHPI CIZ1_HUMAN Decreases Expression [8]
Multiple inositol polyphosphate phosphatase 1 (MINPP1) OTNYPPCC MINP1_HUMAN Increases Expression [8]
Microtubule-associated protein RP/EB family member 3 (MAPRE3) OTSCLETV MARE3_HUMAN Increases Expression [8]
Hexokinase-4 (GCK) OTR3Q0NN HXK4_HUMAN Decreases Expression [30]
Matrilin-2 (MATN2) OTVDR68G MATN2_HUMAN Increases Expression [31]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Increases Expression [32]
Pendrin (SLC26A4) OTXUTLVS S26A4_HUMAN Decreases Expression [32]
ABC-type organic anion transporter ABCA8 (ABCA8) OTCWLX6N ABCA8_HUMAN Decreases Expression [32]
Solute carrier organic anion transporter family member 2B1 (SLCO2B1) OTERJ4VQ SO2B1_HUMAN Increases Expression [32]
ATP-binding cassette sub-family C member 6 (ABCC6) OTZT0LKT MRP6_HUMAN Increases Expression [32]
Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2) OTBL2W7R GTR2_HUMAN Decreases Expression [32]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Increases Expression [32]
Sodium- and chloride-dependent betaine transporter (SLC6A12) OTKOR4F2 S6A12_HUMAN Increases Expression [32]
Sulfate transporter (SLC26A2) OTJNHNTO S26A2_HUMAN Decreases Expression [32]
Amino acid transporter heavy chain SLC3A1 (SLC3A1) OT56V01A SLC31_HUMAN Decreases Expression [32]
Sodium-dependent phosphate transporter 2 (SLC20A2) OT6E2DAX S20A2_HUMAN Decreases Expression [32]
Sodium-coupled monocarboxylate transporter 2 (SLC5A12) OTKY9NAL SC5AC_HUMAN Increases Expression [32]
Long-chain fatty acid transport protein 3 (SLC27A3) OTXB60L7 S27A3_HUMAN Decreases Expression [32]
ATP-binding cassette sub-family C member 10 (ABCC10) OT2JRWWJ MRP7_HUMAN Increases Expression [32]
Solute carrier family 23 member 3 (SLC23A3) OTK1M79V S23A3_HUMAN Decreases Expression [32]
Solute carrier family 25 member 34 (SLC25A34) OTY1YFLG S2534_HUMAN Decreases Expression [32]
Calcium/manganese antiporter SLC30A10 (SLC30A10) OTXM5JW4 ZNT10_HUMAN Decreases Expression [32]
Solute carrier organic anion transporter family member 4C1 (SLCO4C1) OTVILUUN SO4C1_HUMAN Increases Expression [32]
Monocarboxylate transporter 12 (SLC16A12) OTZ63YNA MOT12_HUMAN Decreases Expression [32]
Equilibrative nucleoside transporter 4 (SLC29A4) OTWTZXMX S29A4_HUMAN Increases Expression [32]
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (SLC46A3) OTEMDLPS S46A3_HUMAN Increases Expression [32]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Increases Expression [32]
Organic solute transporter subunit beta (SLC51B) OT4WYPSR OSTB_HUMAN Increases Expression [32]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Expression [32]
ATP-binding cassette sub-family F member 1 (ABCF1) OT6Q079J ABCF1_HUMAN Increases Expression [32]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) OT0EDNV9 GTR12_HUMAN Increases Expression [32]
Sodium/myo-inositol cotransporter 2 (SLC5A11) OTRGCUPZ SC5AB_HUMAN Increases Expression [32]
Multidrug and toxin extrusion protein 1 (SLC47A1) OTZX0U5Q S47A1_HUMAN Increases Expression [32]
ATP-binding cassette sub-family C member 11 (ABCC11) OTVHL7OR MRP8_HUMAN Increases Expression [32]
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) OTALABSK S38A2_HUMAN Decreases Expression [32]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Expression [32]
ATP-binding cassette sub-family G member 8 (ABCG8) OTIJ76XW ABCG8_HUMAN Increases Expression [32]
Mitochondrial glutamate carrier 1 (SLC25A22) OTQGVI1N GHC1_HUMAN Increases Expression [32]
Sodium- and chloride-dependent transporter XTRP3 (SLC6A20) OTHRD4XO S6A20_HUMAN Increases Expression [32]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Decreases Expression [32]
Sodium/hydrogen exchanger 8 (SLC9A8) OTR56QTT SL9A8_HUMAN Increases Expression [32]
Long-chain fatty acid transport protein 5 (SLC27A5) OT4OK511 S27A5_HUMAN Increases Expression [32]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [33]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Expression [34]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [35]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [36]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [37]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Expression [38]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Expression [39]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Decreases Expression [40]
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [41]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Decreases Expression [37]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [42]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Secretion [43]
POU domain, class 2, transcription factor 1 (POU2F1) OTK7ELJ0 PO2F1_HUMAN Decreases Expression [39]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Affects Expression [41]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [44]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Increases Expression [37]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Increases Expression [45]
Glucose-6-phosphatase catalytic subunit 1 (G6PC1) OTJ6FM9F G6PC1_HUMAN Decreases Expression [45]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [44]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Expression [36]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Decreases Expression [37]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [36]
Nuclear receptor subfamily 0 group B member 2 (NR0B2) OT7UVICX NR0B2_HUMAN Decreases Expression [45]
Na(+)/citrate cotransporter (SLC13A5) OTPH1TA7 S13A5_HUMAN Increases Expression [46]
V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1) OT1IK0KA VPP1_HUMAN Increases Expression [47]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [41]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Decreases Metabolism [48]
Serine/threonine-protein kinase Sgk2 (SGK2) OTCTVSHF SGK2_HUMAN Increases Expression [49]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [44]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Expression [39]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Expression [39]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1) OTNEN8QK SO1B1_HUMAN Increases Expression [50]
Arylacetamide deacetylase (AADAC) OT8VACT2 AAAD_HUMAN Decreases Acetylation [51]
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⏷ Show the Full List of 159 DOT(s)

References

1 ClinicalTrials.gov (NCT03801746) Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin
2 ClinicalTrials.gov (NCT03242967) Study to Evaluate Three Times Per Week (TIW) Oral Dosing of Vadadustat for Anemia in Subjects With Dialysis-Dependent Chronic Kidney Disease (DD-CKD) (TRILOGY). U.S. National Institutes of Health.
3 Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation. FEBS Lett. 2001 Oct 26;507(2):200-4.
4 Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children. Cochrane Database Syst Rev. 2022 Sep 6;9(9):CD013359.
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6 The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics. Biochem Pharmacol. 2004 Mar 1;67(5):989-1000.
7 Induction of metabolism and transport in human intestine: validation of precision-cut slices as a tool to study induction of drug metabolism in human intestine in vitro. Drug Metab Dispos. 2008 Mar;36(3):604-13.
8 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
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11 Effects of xenobiotics and peroxisome proliferator-activated receptor-alpha on the human UDPglucose dehydrogenase gene expression. J Biochem Mol Toxicol. 2005;19(5):279-88. doi: 10.1002/jbt.20099.
12 Molecular basis of rifampicin-induced inhibition of anti-CD95-induced apoptosis of peripheral blood T lymphocytes: the role of CD95 ligand and FLIPs. J Clin Immunol. 2003 Jan;23(1):11-22. doi: 10.1023/a:1021944113833.
13 Warfarin-Rifampin-Gene (WARIF-G) Interaction: A?Retrospective, Genetic, Case-Control Study. Clin Pharmacol Ther. 2023 May;113(5):1150-1159. doi: 10.1002/cpt.2871. Epub 2023 Mar 9.
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21 Mechanism of rifampicin inactivation in Nocardia farcinica. PLoS One. 2016 Oct 5;11(10):e0162578.
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24 Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest. 2005 Jan;115(1):177-86.
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31 Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts. Life Sci. 2016 Jun 15;155:29-35.
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33 Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018 Apr;92(4):1435-1451.
34 The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator. Br J Pharmacol. 2016 May;173(10):1703-15. doi: 10.1111/bph.13472. Epub 2016 Apr 8.
35 Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos. 2003 Nov;31(11):1296-9. doi: 10.1124/dmd.31.11.1296.
36 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
37 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
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