Details of the Drug Combination

General Information of Drug Combination (ID: DCEKPM8)

Drug Combination Name
Levobupivacaine Magnesium Sulfate
Indication
Disease Entry Status REF
Analgesia Phase 2 [1]
Component Drugs Levobupivacaine   DM783CH Magnesium Sulfate   DMVEK07
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Levobupivacaine
Disease Entry ICD 11 Status REF
Anaesthesia 9A78.6 Approved [2]
Levobupivacaine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Sodium channel unspecific (NaC) TTRK8B9 NOUNIPROTAC Blocker [5]
------------------------------------------------------------------------------------
Levobupivacaine Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [6]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [7]
------------------------------------------------------------------------------------
Indication(s) of Magnesium Sulfate
Disease Entry ICD 11 Status REF
Acute pain MG31 Approved [3]
Familial primary hypomagnesemia N.A. Approved [4]
Hypertension, pregnancy-induced N.A. Approved [4]
Mild pre-eclampsia N.A. Approved [4]
Non-arteritic anterior ischemic optic neuropathy 9C40.40 Approved [4]
Pain MG30-MG3Z Approved [4]
Severe pre-eclampsia N.A. Approved [4]
Traumatic brain injury NA07.Z Approved [4]
Magnesium Sulfate Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
N-methyl-D-aspartate receptor (NMDAR) TT9IK2Z NOUNIPROTAC Antagonist [8]
------------------------------------------------------------------------------------
Magnesium Sulfate Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Kallikrein-8 (KLK8) OTGVGHXY KLK8_HUMAN Increases Activity [9]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Activity [10]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [11]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [11]
------------------------------------------------------------------------------------

References

1 ClinicalTrials.gov (NCT04275661) Ketamine Versus Magnesium Sulphate as Adjuvants for ESPB in Breast Cancer Surgery
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7211).
3 Emerging drugs for acute ischemic stroke. Expert Opin Emerg Drugs. 2009 Mar;14(1):33-42.
4 Magnesium Sulfate FDA Label
5 Block of neuronal tetrodotoxin-resistant Na+ currents by stereoisomers of piperidine local anesthetics. Anesth Analg. 2000 Dec;91(6):1499-505.
6 Clinical profile of levobupivacaine in regional anesthesia: A systematic review. J Anaesthesiol Clin Pharmacol. 2013 Oct;29(4):530-9.
7 Pharmacokinetics of levobupivacaine after caudal epidural administration in infants less than 3 months of age. Br J Anaesth. 2005 Oct;95(4):524-9.
8 Magnesium sulfate diminishes the effects of amide local anesthetics in rat sciatic-nerve block. Reg Anesth Pain Med. 2007 Jul-Aug;32(4):288-95.
9 Activation and enzymatic characterization of recombinant human kallikrein 8. Biol Chem. 2006 Jun;387(6):723-31. doi: 10.1515/BC.2006.091.
10 Haemodynamic and endocrine effects of deliberate hypotension with magnesium sulphate for cerebral-aneurysm surgery. Eur J Anaesthesiol. 1991 Mar;8(2):115-21.
11 Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.