General Information of Drug Combination (ID: DCFPPZ8)

Drug Combination Name
Sodium bicarbonate Potassium Citrate
Indication
Disease Entry Status REF
Kidney Stone Phase 1 [1]
Component Drugs Sodium bicarbonate   DMMU6BJ Potassium Citrate   DMRBUPA
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Sodium bicarbonate
Disease Entry ICD 11 Status REF
Metabolic acidosis 5C73 Approved [2]
Sodium bicarbonate Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Voltage-gated calcium channel alpha Cav3.2 (CACNA1H) TTZPWGN CAC1H_HUMAN Blocker [5]
Voltage-gated potassium channel Kv4.3 (KCND3) TTPLQO0 KCND3_HUMAN Blocker [6]
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Sodium bicarbonate Interacts with 6 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Sodium-driven chloride bicarbonate exchanger (SLC4A10) DT7RYVF S4A10_HUMAN Substrate [7]
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4) DTWDEIL S4A4_HUMAN Substrate [8]
Electrogenic sodium bicarbonate cotransporter 4 (SLC4A5) DTCL4P8 S4A5_HUMAN Substrate [9]
Sodium bicarbonate cotransporter 3 (SLC4A7) DT03V27 S4A7_HUMAN Substrate [9]
Electroneutral sodium bicarbonate exchanger 1 (SLC4A8) DTW40Z7 S4A8_HUMAN Substrate [9]
Anion exchange protein 4 (SLC4A9) DTSQY0W B3A4_HUMAN Substrate [10]
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⏷ Show the Full List of 6 DTP(s)
Sodium bicarbonate Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Electrogenic sodium bicarbonate cotransporter 1 (SLC4A4) OT727K92 S4A4_HUMAN Increases Transport [11]
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Indication(s) of Potassium Citrate
Disease Entry ICD 11 Status REF
Hypokalemia 5C77 Approved [3]
Kidney stone GB70.0Z Approved [4]
Renal tubular acidosis N.A. Approved [3]

References

1 ClinicalTrials.gov (NCT04651088) Comparing Alkalinizing Agents Efficacy on Stone Risk in Patients on a Metabolically Controlled Diet
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4507).
3 Potassium Citrate FDA Label
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5 Acute renal failure. Clin Evid (Online). 2008 Sep 3;2008. pii: 2001.
6 Management of cocaine-induced cardiac arrhythmias due to cardiac ion channel dysfunction. Clin Toxicol (Phila). 2009 Jan;47(1):14-23.
7 Molecular mechanisms of electrogenic sodium bicarbonate cotransport: structural and equilibrium thermodynamic considerations. J Membr Biol. 2004 Jan 15;197(2):77-90.
8 The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem. 2010 Aug 6;285(32):24432-8.
9 The sodium bicarbonate cotransporter: structure, function, and regulation. Semin Nephrol. 2006 Sep;26(5):352-60.
10 A novel sodium bicarbonate cotransporter-like gene in an ancient duplicated region: SLC4A9 at 5q31. Genome Biol. 2001;2(4):RESEARCH0011.
11 G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis. Am J Physiol Renal Physiol. 2008 Sep;295(3):F633-41. doi: 10.1152/ajprenal.00015.2008. Epub 2008 Jul 9.