Details of the Drug Combination

General Information of Drug Combination (ID: DCI49DI)

Drug Combination Name
Rotigotine Rotigotine
Indication
Disease Entry Status REF
Restless Legs Syndrome Phase 3 [1]
Component Drugs Rotigotine   DMP7X6Q Rotigotine   DMP7X6Q
N.A. N.A.
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Rotigotine Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [2]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [3]
Sulfotransferase 1E1 (SULT1E1) DESTKG6 ST1E1_HUMAN Metabolism [3]
Sulfotransferase 1A2 (SULT1A2) DERUZL7 ST1A2_HUMAN Metabolism [3]
Sulfotransferase 1A3 (SULT1A3) DEP7E8X ST1A3_HUMAN Metabolism [3]
Sulfotransferase 1B1 (SULT1B1) DED5UR3 ST1B1_HUMAN Metabolism [3]
Sulfotransferase 1C4 (SULT1C4) DEU3DHN ST1C4_HUMAN Metabolism [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 7 DME(s)
Rotigotine Interacts with 7 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [2]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [3]
Sulfotransferase 1E1 (SULT1E1) DESTKG6 ST1E1_HUMAN Metabolism [3]
Sulfotransferase 1A2 (SULT1A2) DERUZL7 ST1A2_HUMAN Metabolism [3]
Sulfotransferase 1A3 (SULT1A3) DEP7E8X ST1A3_HUMAN Metabolism [3]
Sulfotransferase 1B1 (SULT1B1) DED5UR3 ST1B1_HUMAN Metabolism [3]
Sulfotransferase 1C4 (SULT1C4) DEU3DHN ST1C4_HUMAN Metabolism [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 7 DME(s)

References

1 ClinicalTrials.gov (NCT03992196) A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome
2 Receptor-binding and pharmacokinetic properties of dopaminergic agonists. Curr Top Med Chem. 2008;8(12):1049-67.
3 Identification of the human SULT enzymes involved in the metabolism of rotigotine. J Clin Pharmacol. 2016 Jun;56(6):754-60.