Details of the Drug Combination

General Information of Drug Combination (ID: DCIOSIR)

Drug Combination Name

Indazole derivative 5 ABIRATERONE

Indication

Disease Entry	Status	REF
Adenocarcinoma	Investigative	[1]

Component Drugs

Indazole derivative 5 DMM1I8R

ABIRATERONE DM8V75C

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: DU-145

Zero Interaction Potency (ZIP) Score: 2.37

Bliss Independence Score: 6.3

Loewe Additivity Score: 4.09

LHighest Single Agent (HSA) Score: 3.52

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indazole derivative 5 Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
ABL T315I mutant (ABL T315I)	TTZJTWA	ABL1_HUMAN	Inhibitor	[3]
Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I)	TTIV39N	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[3]
------------------------------------------------------------------------------------

Indication(s) of ABIRATERONE

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Approved	[2]

ABIRATERONE Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Steroid 17-alpha-monooxygenase (S17AH)	TTRA5BZ	CP17A_HUMAN	Modulator	[4]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Glioma	DCRCGB2	SF-539	Investigative	[5]
Breast adenocarcinoma	DCKEH6T	MDA-MB-468	Investigative	[6]
Colon adenocarcinoma	DCZLSL4	COLO 205	Investigative	[6]
Cutaneous melanoma	DCVUN1Q	SK-MEL-28	Investigative	[1]
Lung adenocarcinoma	DCHXB5F	HOP-62	Investigative	[1]
Melanoma	DCSY3UG	SK-MEL-2	Investigative	[1]
Ovarian serous cystadenocarcinoma	DCJRXF3	SK-OV-3	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 DrugCom(s)

References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3	Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412.
4	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
6	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165