Details of the Drug Combination

General Information of Drug Combination (ID: DCIRC6E)

Drug Combination Name
Vinflunine FORMESTANE
Indication
Disease Entry Status REF
Astrocytoma Investigative [1]
Component Drugs Vinflunine   DMTJAEP FORMESTANE   DMWIDJK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: U251
Zero Interaction Potency (ZIP) Score: 1.72
Bliss Independence Score: 3.94
Loewe Additivity Score: 0.06
LHighest Single Agent (HSA) Score: 0.22

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Vinflunine
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [2]
Indication(s) of FORMESTANE
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Withdrawn from market [2]
FORMESTANE Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [3]
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FORMESTANE Interacts with 2 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Adenylate kinase isoenzyme 1 (AK1) OT614AR3 KAD1_HUMAN Increases ADR [4]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) OT6EBDHM DHB1_HUMAN Decreases Activity [5]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Clear cell renal cell carcinoma DCUSS8J 786-0 Investigative [1]
Glioma DC2KW6N SF-295 Investigative [1]
Adenocarcinoma DC2UVXV DU-145 Investigative [6]
Adenocarcinoma DCCVVGI HCT116 Investigative [6]
Adenocarcinoma DC9OVKE SW-620 Investigative [6]
High grade ovarian serous adenocarcinoma DC165LC NCI\\/ADR-RES Investigative [6]
Large cell lung carcinoma DC5VS0R NCI-H460 Investigative [6]
Lung adenocarcinoma DCCXHOB EKVX Investigative [6]
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⏷ Show the Full List of 8 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 The taiwaniaquinoids: a review. J Nat Prod. 2010 Feb 26;73(2):284-98.
4 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
5 Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells. J Steroid Biochem Mol Biol. 2005 Apr;94(5):461-7.
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976