Details of the Drug Combination

General Information of Drug Combination (ID: DCIY0TV)

Drug Combination Name
Chlorhexidine Mupirocin
Indication
Disease Entry Status REF
Staphylococcal Skin Infections Phase 1 [1]
Component Drugs Chlorhexidine   DMQ9MVG Mupirocin   DMWX683
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Chlorhexidine
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [2]
Gingivitis DA0B Approved [3]
Intracerebral hemorrhage N.A. Approved [3]
Chlorhexidine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Dihydropteroate synthetase (Bact folP) TT4ILYC DHPS_ECOLI Breaker [5]
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Chlorhexidine Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Decreases Activity [6]
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Indication(s) of Mupirocin
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [4]
Mupirocin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Isoleucyl-tRNA synthetase (Bact ileS) TT6KYJ5 SYI_ECOLI Modulator [7]
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References

1 ClinicalTrials.gov (NCT00731783) Staphylococcus Aureus Decolonization Study
2 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019822.
3 Chlorhexidine FDA Label
4 Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
5 The mechanism of action of chlorhexidine. FEMS Microbiol Lett. 1992 Dec 15;79(1-3):211-5.
6 Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition. Environ Health Perspect. 2021 Apr;129(4):47008. doi: 10.1289/EHP6993. Epub 2021 Apr 12.
7 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.