Details of the Drug Combination

General Information of Drug Combination (ID: DCJVFOP)

Drug Combination Name
MK-8616 Rocuronium
Indication
Disease Entry Status REF
High-Frequency Jet Ventilation Phase 1 [1]
Component Drugs MK-8616   DMJRDGC Rocuronium   DMY9BMK
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of MK-8616
Disease Entry ICD 11 Status REF
Poison intoxication NE6Z Approved [2]
Indication(s) of Rocuronium
Disease Entry ICD 11 Status REF
Muscle spasm MB47.3 Approved [3]
Rocuronium Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Neuronal acetylcholine receptor alpha-2 (CHRNA2) TTF4E0J ACHA2_HUMAN Antagonist [4]
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Rocuronium Interacts with 2 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [5]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [6]
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References

1 ClinicalTrials.gov (NCT02888067) Surgical Conditions During Vocal Cord Surgery Requiring Jet Ventilation With Moderate vs. Deep Neuromuscular Block
2 ClinicalTrials.gov (NCT01965067) Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex. U.S. National Institutes of Health.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
5 Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther. 1999 Oct;291(1):147-52.
6 Drug Interactions in Infectious Diseases.