Details of the Drug Combination

General Information of Drug Combination (ID: DCL4VPS)

Drug Combination Name
Vinflunine TEM
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs Vinflunine   DMTJAEP TEM   DMLNFWU
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: A549
Zero Interaction Potency (ZIP) Score: 1.9
Bliss Independence Score: 3.72
Loewe Additivity Score: 1.28
LHighest Single Agent (HSA) Score: 0

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)