Details of the Drug Combination

General Information of Drug Combination (ID: DCLN5KU)

Drug Combination Name
Risedronate Teriparatide
Indication
Disease Entry Status REF
Osteoporosis Phase 1 [1]
Component Drugs Risedronate   DM5FLTY Teriparatide   DMMC45B
Small molecular drug Peptide
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Risedronate
Disease Entry ICD 11 Status REF
Bone Paget disease N.A. Approved [2]
Osteoporosis FB83.0 Approved [2]
Paget's disease FB85 Approved [3]
Risedronate Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Geranyltranstransferase (FDPS) TTIKWV4 FPPS_HUMAN Inhibitor [7]
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Risedronate Interacts with 4 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Ras-related protein Rab-6A (RAB6A) OTLS86J5 RAB6A_HUMAN Decreases Prenylation [8]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [9]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [9]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Decreases Prenylation [10]
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Indication(s) of Teriparatide
Disease Entry ICD 11 Status REF
Exostosis N.A. Approved [4]
Myelofibrosis 2A20.2 Approved [4]
Osteogenesis imperfecta LD24.K0 Approved [5]
Osteoporosis FB83.0 Approved [4]
Psoriatic disorder EA90 Discontinued in Phase 2 [6]
Autosomal dominant hypocalcemia 5A50.0Y Investigative [4]
Teriparatide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Parathyroid hormone (PTH) TT6F7GZ PTHY_HUMAN Modulator [11]
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References

1 ClinicalTrials.gov (NCT01611571) Combination Risedronate - Parathyroid Hormone Trial in Male Osteoporosis
2 Risedronate FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3176).
4 Teriparatide FDA Label
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4448).
6 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030730)
7 Activity of bisphosphonates against Trypanosoma brucei rhodesiense. J Med Chem. 2002 Jul 4;45(14):2904-14.
8 Selective inhibition of Rab prenylation by a phosphonocarboxylate analogue of risedronate induces apoptosis, but not S-phase arrest, in human myeloma cells. Int J Cancer. 2006 Sep 15;119(6):1254-61. doi: 10.1002/ijc.21977.
9 Efficacy of the third-generation bisphosphonate risedronate alone and in combination with anticancer drugs against osteosarcoma cell lines. Anticancer Res. 2008 Jul-Aug;28(4B):2147-54.
10 Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone. 2001 Oct;29(4):336-43. doi: 10.1016/s8756-3282(01)00589-0.
11 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.