Details of the Drug Combination

General Information of Drug Combination (ID: DCLNQLX)

Drug Combination Name
ABIRATERONE Pentostatin
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs ABIRATERONE   DM8V75C Pentostatin   DM0HXDS
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DU-145
Zero Interaction Potency (ZIP) Score: 3.87
Bliss Independence Score: 4.46
Loewe Additivity Score: 3.43
LHighest Single Agent (HSA) Score: 3.53

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of ABIRATERONE
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
ABIRATERONE Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Steroid 17-alpha-monooxygenase (S17AH) TTRA5BZ CP17A_HUMAN Modulator [5]
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Indication(s) of Pentostatin
Disease Entry ICD 11 Status REF
Acute graft versus host disease 4B24.0 Approved [3]
Hairy cell leukaemia 2A82.2 Approved [4]
Leukemia N.A. Approved [3]
Pentostatin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Adenosine deaminase (ADA) TTLP57V ADA_HUMAN Inhibitor [6]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Clear cell renal cell carcinoma DCGLYYH A498 Investigative [7]
Renal cell carcinoma DCEJEU3 UO-31 Investigative [7]
Breast adenocarcinoma DCO9V7V MDA-MB-468 Investigative [8]
Colon adenocarcinoma DCFVFCC COLO 205 Investigative [8]
Cutaneous melanoma DCC5YWI SK-MEL-5 Investigative [1]
Malignant melanoma DC9RPSD LOX IMVI Investigative [1]
Melanoma DCKY0FX SK-MEL-2 Investigative [1]
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⏷ Show the Full List of 7 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3 Pentostatin FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4805).
5 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
6 Purine nucleoside analogs in indolent non-Hodgkin's lymphoma. Oncology (Williston Park). 2000 Jun;14(6 Suppl 2):13-5.
7 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
8 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165