Details of the Drug Combination

General Information of Drug Combination (ID: DCLPFO0)

Drug Combination Name
Arfolitixorin Aminolevulinic Acid Hydrochloride
Indication
Disease Entry Status REF
Adenocarcinoma Investigative [1]
Component Drugs Arfolitixorin   DMIXMYK Aminolevulinic Acid Hydrochloride   DMWNHPC
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: HT29
Zero Interaction Potency (ZIP) Score: 0.93
Bliss Independence Score: 5.88
Loewe Additivity Score: 4.09
LHighest Single Agent (HSA) Score: 7.83

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Arfolitixorin
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 3 [2]
Indication(s) of Aminolevulinic Acid Hydrochloride
Disease Entry ICD 11 Status REF
Actinic keratosis EK90.0 Approved [3]
Aminolevulinic Acid Hydrochloride Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Protoporphyrinogen oxidase (PPOX) TTNFMS9 PPOX_HUMAN Modulator [4]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult T acute lymphoblastic leukemia DC4XK0M MOLT-4 Investigative [5]
Anaplastic large cell lymphoma DCD3VLZ SR Investigative [5]
Invasive ductal carcinoma DCN8QZU BT-549 Investigative [6]
Melanoma DCBRZMT SK-MEL-2 Investigative [1]
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References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2 ClinicalTrials.gov (NCT03750786) A Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer (AGENT). U.S. National Institutes of Health.
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165