Details of the Drug Combination

General Information of Drug Combination (ID: DCLZAYY)

Drug Combination Name
Alogliptin Pioglitazone
Indication
Disease Entry Status REF
Type-2 diabetes Approved [1]
Component Drugs Alogliptin   DM8WI3R Pioglitazone   DMKJ485
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Alogliptin
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Approved [2]
Alogliptin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dipeptidyl peptidase 4 (DPP-4) TTDIGC1 DPP4_HUMAN Inhibitor [7]
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Alogliptin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [8]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [8]
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Alogliptin Interacts with 3 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases ADR [9]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Increases ADR [9]
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Affects Binding [10]
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Indication(s) of Pioglitazone
Disease Entry ICD 11 Status REF
Amyotrophic lateral sclerosis 8B60.0 Approved [3]
Diabetic complication 5A2Y Approved [4]
Non-insulin dependent diabetes 5A11 Approved [3]
Type-2 diabetes 5A11 Phase 3 [5]
Endometriosis GA10 Investigative [3]
Obesity 5B81 Investigative [6]
Pioglitazone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) TTZMAO3 PPARG_HUMAN Agonist [14]
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Pioglitazone Interacts with 4 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [15]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [16]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [17]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Metabolism [18]
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Pioglitazone Interacts with 151 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [19]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Increases Expression [12]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [20]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Decreases Expression [20]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [20]
Peroxisome proliferator-activated receptor alpha (PPARA) OTK095PP PPARA_HUMAN Increases Expression [20]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [21]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [21]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Increases Expression [19]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [22]
Platelet glycoprotein 4 (CD36) OT5CZWKY CD36_HUMAN Increases Expression [22]
Liver carboxylesterase 1 (CES1) OT9L0LR8 EST1_HUMAN Increases Expression [22]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) OTJC60Q7 THIL_HUMAN Decreases Expression [22]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Increases Expression [22]
Perilipin-2 (PLIN2) OTRXJ9UN PLIN2_HUMAN Increases Expression [22]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Decreases Expression [23]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Decreases Expression [23]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [24]
Choriogonadotropin subunit beta variant 1 (CGB1) OT7NFGXF CGB1_HUMAN Increases Expression [11]
Immunoglobulin mu Fc receptor (FCMR) OTI7I47T FCMR_HUMAN Increases Expression [11]
Protein FAM13A (FAM13A) OTZ6GN0Q FA13A_HUMAN Increases Expression [11]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Increases Expression [11]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [11]
Keratin, type II cytoskeletal 6A (KRT6A) OT392M5T K2C6A_HUMAN Decreases Expression [11]
Protein S100-A8 (S100A8) OTVMOB3F S10A8_HUMAN Decreases Expression [11]
Corticoliberin (CRH) OT2MOC4T CRF_HUMAN Increases Expression [11]
Pleckstrin (PLEK) OTB73XXA PLEK_HUMAN Decreases Expression [11]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Decreases Expression [11]
Choriogonadotropin subunit beta 3 (CGB3) OTVM2SU3 CGB3_HUMAN Increases Expression [11]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [11]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [11]
Matrix metalloproteinase-9 (MMP9) OTB2QDAV MMP9_HUMAN Decreases Expression [11]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Decreases Expression [11]
C-C motif chemokine 3-like 1 (CCL3L1) OTQXCYB1 CL3L1_HUMAN Decreases Expression [11]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Decreases Expression [11]
fMet-Leu-Phe receptor (FPR1) OTFF9I6W FPR1_HUMAN Decreases Expression [11]
Glutathione peroxidase 3 (GPX3) OT6PK94R GPX3_HUMAN Increases Expression [11]
Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5) OTZNYEKF GTR5_HUMAN Decreases Expression [11]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Increases Expression [11]
G-protein coupled receptor 183 (GPR183) OTRILX7G GP183_HUMAN Decreases Expression [11]
AP-1 complex subunit sigma-2 (AP1S2) OTZHJFYI AP1S2_HUMAN Decreases Expression [11]
Insulin gene enhancer protein ISL-1 (ISL1) OTVNVKAX ISL1_HUMAN Increases Expression [11]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Decreases Expression [11]
Regulator of G-protein signaling 1 (RGS1) OTGXJYMG RGS1_HUMAN Decreases Expression [11]
Chitotriosidase-1 (CHIT1) OTPQR0A6 CHIT1_HUMAN Decreases Expression [11]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [11]
Four and a half LIM domains protein 1 (FHL1) OTN535SU FHL1_HUMAN Increases Expression [11]
Chorionic somatomammotropin hormone-like 1 (CSHL1) OTQKU2F5 CSHL_HUMAN Increases Expression [11]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [11]
Fascin (FSCN1) OTTGIHTM FSCN1_HUMAN Decreases Expression [11]
Ankyrin repeat domain-containing protein SOWAHC (SOWAHC) OTI86ECP SWAHC_HUMAN Increases Expression [11]
Mitochondrial amidoxime-reducing component 1 (MTARC1) OTNBE033 MARC1_HUMAN Increases Expression [11]
Isthmin-2 (ISM2) OT4K7KON ISM2_HUMAN Increases Expression [11]
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24) OT3ZNGEL SCMC1_HUMAN Decreases Expression [11]
SPOC domain-containing protein 1 (SPOCD1) OTF4K46N SPOC1_HUMAN Increases Expression [11]
Transmembrane protein 91 (TMEM91) OT6AQNY8 TMM91_HUMAN Increases Expression [11]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Increases Expression [11]
Mast cell-expressed membrane protein 1 (MCEMP1) OTCZC9ZM MCEM1_HUMAN Increases Expression [11]
Retinol dehydrogenase 10 (RDH10) OTL9FSGF RDH10_HUMAN Increases Expression [11]
Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2) OT1O2K47 LIRA2_HUMAN Decreases Expression [11]
C-type lectin domain family 1 member A (CLEC1A) OTG7Q02A CLC1A_HUMAN Increases Expression [11]
Prostamide/prostaglandin F synthase (PRXL2B) OTY5G543 PXL2B_HUMAN Decreases Expression [11]
Uncharacterized protein C1orf54 (C1ORF54) OTXFDXKJ CA054_HUMAN Decreases Expression [11]
MICOS complex subunit MIC25 (CHCHD6) OT8F9BHW MIC25_HUMAN Decreases Expression [11]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2) OTZ092ZJ THIC_HUMAN Decreases Expression [11]
Angiopoietin-related protein 4 (ANGPTL4) OTQL5SPX ANGL4_HUMAN Increases Expression [11]
Very long chain fatty acid elongase 4 (ELOVL4) OT2M9W26 ELOV4_HUMAN Increases Expression [11]
Membrane-spanning 4-domains subfamily A member 7 (MS4A7) OT4X45JZ MS4A7_HUMAN Increases Expression [11]
B-cell lymphoma/leukemia 11A (BCL11A) OTI6ZBP6 BC11A_HUMAN Decreases Expression [11]
Regulator of cell cycle RGCC (RGCC) OTYJMLWM RGCC_HUMAN Decreases Expression [11]
Transducin-like enhancer protein 6 (TLE6) OTB84O0U TLE6_HUMAN Increases Expression [11]
Endogenous retroviral envelope protein HEMO (ERVMER34-1) OTECWJ0Y MER34_HUMAN Increases Expression [11]
Nicotinamide riboside kinase 2 (NMRK2) OTMSLE39 NRK2_HUMAN Decreases Expression [11]
GTPase IMAP family member 4 (GIMAP4) OTEUZH06 GIMA4_HUMAN Decreases Expression [11]
SLAM family member 5 (CD84) OTAY5B0F SLAF5_HUMAN Decreases Expression [11]
Procollagen C-endopeptidase enhancer 2 (PCOLCE2) OTSUEQZ1 PCOC2_HUMAN Increases Expression [11]
C-type lectin domain family 4 member A (CLEC4A) OTNLPK2C CLC4A_HUMAN Decreases Expression [11]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Affects Localization [12]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [12]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Increases Expression [25]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Decreases Expression [13]
Unconventional myosin-Ic (MYO1C) OT69L39Y MYO1C_HUMAN Increases Expression [13]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [13]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [26]
Nephrin (NPHS1) OT21JD3P NPHN_HUMAN Increases Expression [27]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [26]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Decreases Expression [28]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [29]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [13]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [30]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [31]
Protein kinase C gamma type (PRKCG) OTW52VNZ KPCG_HUMAN Increases Expression [13]
ATP synthase subunit beta, mitochondrial (ATP5F1B) OTLFZUQK ATPB_HUMAN Decreases Expression [32]
Protein S100-A9 (S100A9) OTOARHCS S10A9_HUMAN Increases Expression [33]
Hepatocyte growth factor receptor (MET) OT7K55MU MET_HUMAN Increases Expression [26]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Decreases Response To Substance [34]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [35]
Fatty acid-binding protein, adipocyte (FABP4) OT3DKFOU FABP4_HUMAN Increases Expression [36]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Decreases Expression [13]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [35]
Bone morphogenetic protein 6 (BMP6) OT9WN536 BMP6_HUMAN Increases Expression [26]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Decreases Phosphorylation [37]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [37]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [35]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Expression [35]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Phosphorylation [37]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Phosphorylation [37]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [35]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [26]
Basigin (BSG) OTD0CVEC BASI_HUMAN Decreases Expression [38]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [35]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [13]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [37]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Decreases Response To Substance [34]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Expression [13]
Oxysterols receptor LXR-beta (NR1H2) OT4APA60 NR1H2_HUMAN Increases Expression [39]
Beta-secretase 1 (BACE1) OTCA7B6A BACE1_HUMAN Decreases Expression [40]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Increases Expression [13]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [13]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Expression [13]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Increases Expression [13]
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) OT83PT85 PP2AA_HUMAN Increases Expression [13]
Nucleobindin-2 (NUCB2) OTHO6JWN NUCB2_HUMAN Increases Stability [41]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Increases Expression [26]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PPP2R2B) OTSFVC82 2ABB_HUMAN Increases Expression [13]
Transcription factor A, mitochondrial (TFAM) OTXXV5V7 TFAM_HUMAN Decreases Expression [32]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Affects Expression [42]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [39]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [26]
Phospholipase D1 (PLD1) OTMVUKW6 PLD1_HUMAN Decreases Expression [13]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Decreases Expression [13]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Increases Expression [13]
Eukaryotic translation initiation factor 4E-binding protein 2 (EIF4EBP2) OT3M8WEU 4EBP2_HUMAN Increases Expression [13]
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) OT8RPSOC FKBP8_HUMAN Increases Expression [13]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2) OTIOYUSU KS6A2_HUMAN Increases Expression [13]
GTP-binding protein Rheb (RHEB) OTFLTSEC RHEB_HUMAN Increases Expression [13]
Ribosomal protein S6 kinase alpha-1 (RPS6KA1) OTDOTWU4 KS6A1_HUMAN Increases Expression [13]
Serine/threonine-protein kinase STK11 (STK11) OT1YZSP3 STK11_HUMAN Increases Expression [13]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Increases Expression [43]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [13]
PTB-containing, cubilin and LRP1-interacting protein (PID1) OT5YJ7FI PCLI1_HUMAN Increases Expression [26]
Regulatory-associated protein of mTOR (RPTOR) OT4TQZ9F RPTOR_HUMAN Increases Phosphorylation [37]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) OTI0DU9Y PCSK9_HUMAN Increases Expression [44]
Intelectin-1 (ITLN1) OT7ZLJVV ITLN1_HUMAN Increases Expression [45]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Increases Activity [46]
DNA damage-inducible transcript 4-like protein (DDIT4L) OT26Z2KN DDT4L_HUMAN Increases Expression [13]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Decreases Expression [47]
Fibroblast growth factor 21 (FGF21) OT3RXVRD FGF21_HUMAN Increases Expression [48]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Increases Expression [13]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Increases Expression [26]
Telomere length regulation protein TEL2 homolog (TELO2) OT2YQ9L8 TELO2_HUMAN Increases Expression [13]
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⏷ Show the Full List of 151 DOT(s)

References

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26 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
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28 Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss. BMC Endocr Disord. 2017 Jul 14;17(1):41. doi: 10.1186/s12902-017-0194-2.
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