Details of the Drug Combination

General Information of Drug Combination (ID: DCNC4GN)

Drug Combination Name
Estramustine RTB101
Indication
Disease Entry Status REF
Colon adenocarcinoma Investigative [1]
Component Drugs Estramustine   DMWTAOI RTB101   DM62QTW
Small molecular drug Small molecular drug
High-throughput Screening Result Testing Cell Line: LOVO
Zero Interaction Potency (ZIP) Score: 1.7
Bliss Independence Score: 0.52
Loewe Additivity Score: 2.83
LHighest Single Agent (HSA) Score: 5.44

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Estramustine
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
Estramustine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Estramustine binding protein (EMBP) TTSBFYK NOUNIPROTAC Binder [5]
------------------------------------------------------------------------------------
Estramustine Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [6]
------------------------------------------------------------------------------------
Estramustine Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Keratin, type I cytoskeletal 18 (KRT18) OTVLQFIP K1C18_HUMAN Increases Expression [7]
------------------------------------------------------------------------------------
Indication(s) of RTB101
Disease Entry ICD 11 Status REF
Respiratory tract infection CA45 Phase 3 [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
RTB101 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
CREB-regulated transcription coactivator 1 (TORC1) TT4GO0F CRTC1_HUMAN Inhibitor [8]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Ewing sarcoma-peripheral primitive neuroectodermal tumour DCV8NO5 ES2 Investigative [9]
Breast and ovarian cancer syndrome DC4XUI4 UWB1289 Investigative [1]
Breast and ovarian cancer syndrome DC3GT33 UWB1289+BRCA1 Investigative [1]
Breast carcinoma DCNYEZ5 OCUBM Investigative [1]
Carcinoma DC29LSD OV90 Investigative [1]
Carcinoma DCFL1OS EFM192B Investigative [1]
Invasive ductal carcinoma DC3CRWQ T-47D Investigative [1]
Adenocarcinoma DCMD25L CAOV3 Investigative [10]
Adenocarcinoma DC570BS A427 Investigative [10]
Adenocarcinoma DCZS4BT NCIH2122 Investigative [10]
Adenocarcinoma DCBUFC7 NCIH23 Investigative [10]
Adenocarcinoma DCVWAVK NCIH520 Investigative [10]
Adenocarcinoma DCVH6SS DLD1 Investigative [10]
Adenocarcinoma DC0T7S2 HT29 Investigative [10]
Adenocarcinoma DC9S79Y SW-620 Investigative [10]
Amelanotic melanoma DCQ7QFU A2058 Investigative [10]
Germ cell tumour DCZYUWT PA1 Investigative [10]
Large cell lung carcinoma DCSWDPY NCI-H460 Investigative [10]
Malignant melanoma DCSDG9F A375 Investigative [10]
Malignant melanoma DCSC9W4 HT144 Investigative [10]
Malignant melanoma DCAIK3M RPMI7951 Investigative [10]
Malignant melanoma DCK7ZE1 SKMEL30 Investigative [10]
Mesothelioma DC1SDJJ MSTO Investigative [10]
Non small cell carcinoma DC862TP SKMES1 Investigative [10]
Ovarian endometrioid adenocarcinoma DC8ZEIC A2780 Investigative [10]
Ovarian serous cystadenocarcinoma DC8BFJC SK-OV-3 Investigative [10]
------------------------------------------------------------------------------------
⏷ Show the Full List of 26 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
2 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3 ClinicalTrials.gov (NCT04139915) Effect of RTB101 on Illness Associated With Respiratory Tract Infections in the Elderly. U.S. National Institutes of Health.
4 ClinicalTrials.gov (NCT04409327) Phase 2 Study to Determine if RTB101 Reduces the Severity of COVID-19 in Older Adults Residing in Nursing Homes. U.S. National Institutes of Health.
5 Estramustine binding protein in primary tumours and metastases of malignant melanoma. Melanoma Res. 1994 Dec;4(6):401-5.
6 Activity of docetaxel with or without estramustine phosphate versus mitoxantrone in androgen dependent and independent human prostate cancer xenografts. J Urol. 2003 May;169(5):1729-34.
7 Docetaxel induces apoptosis in hormone refractory prostate carcinomas during multiple treatment cycles. Br J Cancer. 2006 Jun 5;94(11):1592-8. doi: 10.1038/sj.bjc.6603129.
8 Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612.
9 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
10 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976