General Information of Drug Combination (ID: DCNENWO)

Drug Combination Name
MK-4815 MK-4815
Indication
Disease Entry Status REF
DD2 Investigative [1]
Component Drugs MK-4815   DMT9K74 MK-4815   DMT9K74
N.A. N.A.
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DD2
Zero Interaction Potency (ZIP) Score: 11.597
Bliss Independence Score: 15.351
Loewe Additivity Score: 0.1
LHighest Single Agent (HSA) Score: 0.931

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.