Details of the Drug Combination

General Information of Drug Combination (ID: DCNHKCN)

Drug Combination Name
ABIRATERONE Terameprocol
Indication
Disease Entry Status REF
Colon adenocarcinoma Investigative [1]
Component Drugs ABIRATERONE   DM8V75C Terameprocol   DMC3P45
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: COLO 205
Zero Interaction Potency (ZIP) Score: 1.38
Bliss Independence Score: 7.02
Loewe Additivity Score: 2.68
LHighest Single Agent (HSA) Score: 3.08

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of ABIRATERONE
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
ABIRATERONE Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Steroid 17-alpha-monooxygenase (S17AH) TTRA5BZ CP17A_HUMAN Modulator [4]
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Indication(s) of Terameprocol
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Terameprocol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Transcription factor Sp1 (SP1) TTZEP6S SP1_HUMAN Modulator [3]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DC5446Y HL-60(TB) Investigative [5]
Clear cell renal cell carcinoma DCDOT6F A498 Investigative [5]
Clear cell renal cell carcinoma DC0XUK7 CAKI-1 Investigative [5]
Adenocarcinoma DC8Z38C DU-145 Investigative [6]
Adenocarcinoma DCSSIRZ HCT116 Investigative [6]
High grade ovarian serous adenocarcinoma DCZQLF8 OVCAR-5 Investigative [6]
Large cell lung carcinoma DCNYSY3 NCI-H460 Investigative [6]
Lung adenocarcinoma DC5I5LR EKVX Investigative [6]
Melanoma DC5UWPI SK-MEL-2 Investigative [6]
Non-small cell lung carcinoma DC2VEVL HOP-92 Investigative [6]
Ovarian serous cystadenocarcinoma DCTXO9W SK-OV-3 Investigative [6]
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⏷ Show the Full List of 11 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3 Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. IDrugs. 2008 Mar;11(3):204-14.
4 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976