Details of the Drug Combination

General Information of Drug Combination (ID: DCO28PY)

• Drug Combination Name: Brincidofovir + Doxapram
• Indication: Chronic myelogenous leukemia; Status: Investigative [1]
• Component Drugs:
  Brincidofovir (DMS0PND): Small molecular drug
  Doxapram (DMCYANK): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: KBM-7
  Zero Interaction Potency (ZIP) Score: 6.67
  Bliss Independence Score: 6.67
  Loewe Additivity Score: 7.34
  LHighest Single Agent (HSA) Score: 7.37

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Brincidofovir

Disease Entry	ICD 11	Status	REF
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]

Indication(s) of Doxapram

Disease Entry	ICD 11	Status	REF
Respiratory disease	CB40	Approved	[3]

Doxapram Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Peripheral carotid chemoreceptor (PCC)	TT6EYVN	NOUNIPROTAC	Stimulator	[4]

Doxapram Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[5]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[5]

References

• [1] CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
• [2] A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29. Br J Pharmacol. 2020 May 1;10.1111/bph.15094.
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7169).
• [4] Ovalbumin sensitization alters the ventilatory responses to chemical challenges in guinea pigs. J Appl Physiol (1985). 2005 Nov;99(5):1782-8.
• [5] Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr. 2015 Apr;174(4):509-18.