Details of the Drug Combination

General Information of Drug Combination (ID: DCOIL69)

Drug Combination Name

ABIRATERONE Bendamustine hydrochloride

Indication

Disease Entry	Status	REF
Melanoma	Investigative	[1]

Component Drugs

ABIRATERONE DM8V75C

Bendamustine hydrochloride DMFH15Z

Small molecular drug

2D MOL

3D MOL

3D MOL is unavailable

High-throughput Screening Result

Testing Cell Line: UACC-257

Zero Interaction Potency (ZIP) Score: 7.84

Bliss Independence Score: 10.22

Loewe Additivity Score: 3.25

LHighest Single Agent (HSA) Score: 9.71

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of ABIRATERONE

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Approved	[2]

ABIRATERONE Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Steroid 17-alpha-monooxygenase (S17AH)	TTRA5BZ	CP17A_HUMAN	Modulator	[4]
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Indication(s) of Bendamustine hydrochloride

Disease Entry	ICD 11	Status	REF
leukaemia	2A60-2B33	Approved	[3]

Bendamustine hydrochloride Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Modulator	[3]
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Bendamustine hydrochloride Interacts with 1 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[6]
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Bendamustine hydrochloride Interacts with 6 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[5]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[5]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Decreases Expression	[7]
PRKC apoptosis WT1 regulator protein (PAWR)	OTKY7W52	PAWR_HUMAN	Decreases Expression	[5]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Localization	[5]
Death domain-associated protein 6 (DAXX)	OTX6O7PL	DAXX_HUMAN	Decreases Expression	[5]
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⏷ Show the Full List of 6 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCHCLB1	HL-60(TB)	Investigative	[8]
Adult T acute lymphoblastic leukemia	DCXSJSM	MOLT-4	Investigative	[8]
Clear cell renal cell carcinoma	DCSHW7D	786-0	Investigative	[8]
Clear cell renal cell carcinoma	DCCXZ32	TK-10	Investigative	[8]
Renal cell carcinoma	DCMJWP0	UO-31	Investigative	[8]
Breast adenocarcinoma	DCO0EXY	MDA-MB-468	Investigative	[9]
Invasive ductal carcinoma	DC6LR8H	BT-549	Investigative	[9]
Adenocarcinoma	DCKRQU7	A549	Investigative	[1]
Adenocarcinoma	DCDIWR7	HCT116	Investigative	[1]
Adenocarcinoma	DCGV9FW	SW-620	Investigative	[1]
Amelanotic melanoma	DCKV1IP	M14	Investigative	[1]
Cutaneous melanoma	DCCJYNP	SK-MEL-28	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCKY211	OVCAR-8	Investigative	[1]
Large cell lung carcinoma	DC11VK3	NCI-H460	Investigative	[1]
Malignant melanoma	DCBJCN0	UACC62	Investigative	[1]
Melanoma	DC9MRLN	MALME-3M	Investigative	[1]
Mixed endometrioid and clear cell carcinoma	DC4RKBX	IGROV1	Investigative	[1]
Prostate carcinoma	DC2YDX0	PC-3	Investigative	[1]
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⏷ Show the Full List of 18 DrugCom(s)

References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3	2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6.
4	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5	Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6.
6	Pharmacokinetic and pharmacodynamic profile of bendamustine and its metabolites. Cancer Chemother Pharmacol. 2015 Jun;75(6):1143-54.
7	Upon drug-induced apoptosis in lymphoma cells X-linked inhibitor of apoptosis (XIAP) translocates from the cytosol to the nucleus. Leuk Lymphoma. 2004 Jul;45(7):1429-36. doi: 10.1080/1042819042000198858.
8	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
9	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165