Details of the Drug Combination

General Information of Drug Combination (ID: DCOZHPF)

• Drug Combination Name: Piperaquine + OZ277
• Indication: Hepatoblastoma; Status: Investigative [1]
• Component Drugs:
  Piperaquine (DMT70RC): Small molecular drug
  OZ277 (DM1YB0R): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: HB3
  Zero Interaction Potency (ZIP) Score: 2.334
  Bliss Independence Score: 2.916
  Loewe Additivity Score: 1.018
  LHighest Single Agent (HSA) Score: 3.546

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Piperaquine

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Approved	[2]

Piperaquine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)	TTZVSJ2	NOUNIPROTAC	Inhibitor	[2]

Piperaquine Interacts with 2 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[3]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[4]

Indication(s) of OZ277

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Approved	[2]

OZ277 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A)	TTZVSJ2	NOUNIPROTAC	Inhibitor	[2]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
DD2	DCH9CG0	DD2	Investigative	[5]

References

• [1] CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
• [2] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [3] Eurartesim - European Medicines Agency
• [4] Open-label crossover study of primaquine and dihydroartemisinin-piperaquine pharmacokinetics in healthy adult thai subjects. Antimicrob Agents Chemother. 2014 Dec;58(12):7340-6.
• [5] CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966