Details of the Drug Combination

General Information of Drug Combination (ID: DCPWALV)

Drug Combination Name
Semaglutide Semaglutide
Indication
Disease Entry Status REF
Diabetes Mellitus, Type 2 Phase 1 [1]
Component Drugs Semaglutide   DMAGFOD Semaglutide   DMAGFOD
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Semaglutide
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Approved [2]
Semaglutide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucagon-like peptide 1 receptor (GLP1R) TTVIMDE GLP1R_HUMAN Agonist [3]
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Semaglutide Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Dipeptidyl peptidase IV (DPP4) DEKZQY6 DPP4_HUMAN Metabolism [4]
Neprilysin (MME) DEVN830 NEP_HUMAN Metabolism [4]
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Indication(s) of Semaglutide
Disease Entry ICD 11 Status REF
Type-2 diabetes 5A11 Approved [2]
Semaglutide Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucagon-like peptide 1 receptor (GLP1R) TTVIMDE GLP1R_HUMAN Agonist [3]
------------------------------------------------------------------------------------
Semaglutide Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Dipeptidyl peptidase IV (DPP4) DEKZQY6 DPP4_HUMAN Metabolism [4]
Neprilysin (MME) DEVN830 NEP_HUMAN Metabolism [4]
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References

1 ClinicalTrials.gov (NCT03611322) A Trial to Compare Blood Concentration Levels of Semaglutide Following Subcutaneous Injections of Semaglutide 1 mg by 2 Different Devices (the DV3372 Device and by the PDS290 Semaglutide Pen-injector)
2 2017 FDA drug approvals.Nat Rev Drug Discov. 2018 Feb;17(2):81-85.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 249).
4 Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41.