Details of the Drug Combination

General Information of Drug Combination (ID: DCQ9E5K)

Drug Combination Name

Fenoldopam Acetylcysteine

Indication

Disease Entry	Status	REF
Kidney Failure, Acute	Phase 1	[1]

Component Drugs

Fenoldopam DMFAOKP

Acetylcysteine DMWSXI4

Small molecular drug

2D MOL

3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Fenoldopam

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[2]

Fenoldopam Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Dopamine D1 receptor (D1R)	TTZFYLI	DRD1_HUMAN	Agonist	[5]
------------------------------------------------------------------------------------

Indication(s) of Acetylcysteine

Disease Entry	ICD 11	Status	REF
Amyloidosis	5D00	Approved	[3]
Bronchiectasis	CA24	Approved	[3]
Bronchitis	CA20	Approved	[3]
Bulimia nervosa	6B81	Approved	[3]
Ischemia-reperfusion injury	DB98.B	Approved	[3]
Liver disease	DB90-BD99	Approved	[4]
Paracetamol poisoning	N.A.	Approved	[3]

References

1	ClinicalTrials.gov (NCT00122018) An Investigation of N-acetylcysteine and Fenoldopam as Renal Protection Agents for Cardiac Surgery
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 985).
3	Acetylcysteine FDA Label
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5	Etiology of iodinated radiocontrast nephrotoxicity and its attenuation by beraprost. Yakugaku Zasshi. 2008 Jul;128(7):1023-9.