Details of the Drug Combination

General Information of Drug Combination (ID: DCSCE32)

Drug Combination Name
ABIRATERONE SY-1425
Indication
Disease Entry Status REF
Melanoma Investigative [1]
Component Drugs ABIRATERONE   DM8V75C SY-1425   DMH8UF0
Small molecular drug N.A.
High-throughput Screening Result Testing Cell Line: SK-MEL-2
Zero Interaction Potency (ZIP) Score: 6.93
Bliss Independence Score: 4.03
Loewe Additivity Score: 2.22
LHighest Single Agent (HSA) Score: 0.76

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of ABIRATERONE
Disease Entry ICD 11 Status REF
Prostate cancer 2C82.0 Approved [2]
ABIRATERONE Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Steroid 17-alpha-monooxygenase (S17AH) TTRA5BZ CP17A_HUMAN Modulator [4]
------------------------------------------------------------------------------------
Indication(s) of SY-1425
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1 [3]
Myelodysplastic syndrome 2A37 Phase 1 [3]
SY-1425 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Retinoic acid receptor alpha (RARA) TTW38KT RARA_HUMAN Agonist [3]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult acute myeloid leukemia DC2HLXJ HL-60(TB) Investigative [5]
Childhood T acute lymphoblastic leukemia DCN52PI CCRF-CEM Investigative [5]
Chronic myelogenous leukemia DC26CJX K-562 Investigative [5]
Plasma cell myeloma DCUW77F RPMI-8226 Investigative [5]
Renal cell carcinoma DC1XX9N UO-31 Investigative [5]
Breast adenocarcinoma DCWAY8F MDA-MB-468 Investigative [6]
Adenocarcinoma DC1M1C9 HT29 Investigative [1]
High grade ovarian serous adenocarcinoma DC6S94P OVCAR-8 Investigative [1]
Malignant melanoma DCAEKCR LOX IMVI Investigative [1]
Melanoma DC73WH3 MALME-3M Investigative [1]
Minimally invasive lung adenocarcinoma DC8K94B NCI-H322M Investigative [1]
------------------------------------------------------------------------------------
⏷ Show the Full List of 11 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165