Details of the Drug Combination

General Information of Drug Combination (ID: DCSM80Q)

Drug Combination Name
Fosmidomycin OZ277
Indication
Disease Entry Status REF
Hepatoblastoma Investigative [1]
Component Drugs Fosmidomycin   DM7G0EP OZ277   DM1YB0R
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: HB3
Zero Interaction Potency (ZIP) Score: 3.278
Bliss Independence Score: 2.523
Loewe Additivity Score: 0.157
LHighest Single Agent (HSA) Score: 3.709

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Fosmidomycin
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [2]
Fosmidomycin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Plasmodium DOXP reductoisomerase (Malaria DXR) TTLH4J3 DXR_PLAFX Binder [3]
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Indication(s) of OZ277
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [2]
OZ277 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) TTZVSJ2 NOUNIPROTAC Inhibitor [2]
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References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
3 Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the cata... J Biol Chem. 2003 May 16;278(20):18401-7.