Details of the Drug Combination

General Information of Drug Combination (ID: DCSZI8V)

Drug Combination Name
BIO-300 LIAROZOLE
Indication
Disease Entry Status REF
Astrocytoma Investigative [1]
Component Drugs BIO-300   DMJ7NVI LIAROZOLE   DM4OYXE
N.A. Small molecular drug
High-throughput Screening Result Testing Cell Line: SNB-19
Zero Interaction Potency (ZIP) Score: 0.48
Bliss Independence Score: 1.61
Loewe Additivity Score: 1.05
LHighest Single Agent (HSA) Score: 4.11

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of BIO-300
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
Rheumatoid arthritis FA20 Phase 1 [3]
Indication(s) of LIAROZOLE
Disease Entry ICD 11 Status REF
Dermatological disease DA24.Y Phase 2/3 [4]
LIAROZOLE Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aromatase (CYP19A1) TTSZLWK CP19A_HUMAN Inhibitor [5]
Cytochrome P450 26 (CYP26A1) TTD7Q0R CP26A_HUMAN Inhibitor [6]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Glioma DCY6SA2 SF-268 Investigative [1]
Colon adenocarcinoma DC9462R COLO 205 Investigative [7]
Adenocarcinoma DCKRB3O HCT116 Investigative [8]
Adenocarcinoma DC7Q019 SW-620 Investigative [8]
Mixed endometrioid and clear cell carcinoma DCH0KN3 IGROV1 Investigative [8]
------------------------------------------------------------------------------------

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2 Clinical pipeline report, company report or official report of Humanetics.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5210).
5 Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorg Med Chem Lett. 2010 May 15;20(10):3050-64.
6 Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells. Bioorg Med Chem. 2008 Sep 1;16(17):8301-13.
7 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
8 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976