Details of the Drug Combination

General Information of Drug Combination (ID: DCT94H7)

Drug Combination Name

ABIRATERONE PMID28870136-Compound-43

Indication

Disease Entry	Status	REF
Cutaneous melanoma	Investigative	[1]

Component Drugs

ABIRATERONE DM8V75C

PMID28870136-Compound-43 DMWGV8N

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: SK-MEL-5

Zero Interaction Potency (ZIP) Score: 3.72

Bliss Independence Score: 7.51

Loewe Additivity Score: 6.01

LHighest Single Agent (HSA) Score: 2.43

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of ABIRATERONE

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Approved	[2]

ABIRATERONE Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Steroid 17-alpha-monooxygenase (S17AH)	TTRA5BZ	CP17A_HUMAN	Modulator	[3]
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PMID28870136-Compound-43 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Ecto-5'-nucleotidase (CD73)	TTK0O6Y	5NTD_HUMAN	Inhibitor	[4]
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Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCJLIM7	HL-60(TB)	Investigative	[5]
Melanoma	DCF0FQX	SK-MEL-2	Investigative	[1]
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References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6745).
3	2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
4	Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
5	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966