Details of the Drug Combination

General Information of Drug Combination (ID: DCVQ1UG)

Drug Combination Name
TEM Aminolevulinic Acid Hydrochloride
Indication
Disease Entry Status REF
Adult acute myeloid leukemia Investigative [1]
Component Drugs TEM   DMLNFWU Aminolevulinic Acid Hydrochloride   DMWNHPC
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: HL-60(TB)
Zero Interaction Potency (ZIP) Score: 5.54
Bliss Independence Score: 6.63
Loewe Additivity Score: 3.29
LHighest Single Agent (HSA) Score: 4.03

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]
Indication(s) of Aminolevulinic Acid Hydrochloride
Disease Entry ICD 11 Status REF
Actinic keratosis EK90.0 Approved [3]
Aminolevulinic Acid Hydrochloride Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Protoporphyrinogen oxidase (PPOX) TTNFMS9 PPOX_HUMAN Modulator [4]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Glioma DCUB7LJ SF-268 Investigative [1]
Papillary renal cell carcinoma DCSVA1P ACHN Investigative [1]
Invasive ductal carcinoma DCVI4ZS T-47D Investigative [5]
Invasive ductal carcinoma DCBV0GM BT-549 Investigative [5]
Adenocarcinoma DCNZPHC DU-145 Investigative [6]
Adenocarcinoma DCQN8Y1 A549 Investigative [6]
Large cell lung carcinoma DC31L29 NCI-H460 Investigative [6]
Lung adenocarcinoma DC1CKPZ HOP-62 Investigative [6]
Melanoma DCDGDPN MALME-3M Investigative [6]
------------------------------------------------------------------------------------
⏷ Show the Full List of 9 DrugCom(s)

References

1 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
5 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1126165
6 CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976