Details of the Drug Combination

General Information of Drug Combination (ID: DCWH9M9)

Drug Combination Name
Gefitinib Mifepristone
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs Gefitinib   DM15F0X Mifepristone   DMGZQEF
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: SU-DIPG-XIII
Zero Interaction Potency (ZIP) Score: 5.04
Bliss Independence Score: 11.874
Loewe Additivity Score: 0.611
LHighest Single Agent (HSA) Score: 0.998

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Gefitinib
Disease Entry ICD 11 Status REF
Colon adenocarcinoma N.A. Approved [2]
Glioblastoma 2A00 Approved [2]
Lung cancer 2C25.0 Approved [2]
Non-small-cell lung cancer 2C25.Y Approved [2]
Rectal adenocarcinoma 2B92 Approved [2]
Rectum mucinous adenocarcinoma N.A. Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [3]
Head and neck cancer 2D42 Phase 3 [3]
Urethral cancer 2C93 Phase 2 [3]
Colon cancer 2B90.Z Investigative [2]
Colon mucinous adenocarcinoma N.A. Investigative [2]
Gefitinib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Epidermal growth factor receptor (EGFR) TTGKNB4 EGFR_HUMAN Inhibitor [10]
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Gefitinib Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [12]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [13]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [13]
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Gefitinib Interacts with 3 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [14]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [15]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [14]
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Gefitinib Interacts with 64 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases ADR [16]
Sulfhydryl oxidase 1 (QSOX1) OT4ZPK4P QSOX1_HUMAN Increases Expression [17]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Decreases Expression [17]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [17]
Fibroblast growth factor 6 (FGF6) OTRJ679P FGF6_HUMAN Increases Expression [17]
Ski oncogene (SKI) OT4KJ8F6 SKI_HUMAN Increases Expression [17]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [17]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Decreases Expression [17]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [17]
Replication protein A 70 kDa DNA-binding subunit (RPA1) OT76POLP RFA1_HUMAN Increases Expression [17]
Adenosine receptor A1 (ADORA1) OTI7X39E AA1R_HUMAN Decreases Expression [17]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Decreases Expression [17]
Glycine--tRNA ligase (GARS1) OT5B6R9Y GARS_HUMAN Increases Expression [17]
Epidermal growth factor receptor substrate 15 (EPS15) OT7NPP8U EPS15_HUMAN Increases Expression [17]
Neural retina-specific leucine zipper protein (NRL) OT65MFKQ NRL_HUMAN Decreases Expression [17]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (GNB2) OT3JPRCQ GBB2_HUMAN Decreases Expression [17]
Retinal guanylyl cyclase 1 (GUCY2D) OT81UJI0 GUC2D_HUMAN Decreases Expression [17]
Cell growth regulator with RING finger domain protein 1 (CGRRF1) OTLMNRCL CGRF1_HUMAN Increases Expression [17]
Dual specificity protein phosphatase 9 (DUSP9) OTZZWEQL DUS9_HUMAN Decreases Expression [17]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [18]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [19]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [20]
Ubiquitin-like modifier-activating enzyme ATG7 (ATG7) OTVT4YA1 ATG7_HUMAN Increases Expression [21]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [22]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Phosphorylation [23]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA) OTZE5Q7R DOA_HUMAN Affects Expression [24]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Increases Secretion [25]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [26]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Secretion [27]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Secretion [25]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Expression [28]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Expression [28]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [29]
HLA class I histocompatibility antigen, alpha chain F (HLA-F) OT76CM19 HLAF_HUMAN Affects Expression [24]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [20]
Cyclin-dependent kinase 4 inhibitor B (CDKN2B) OTAG24N1 CDN2B_HUMAN Increases Expression [22]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Decreases Phosphorylation [6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [29]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Response To Substance [30]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [26]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [31]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Increases Expression [32]
MHC class I polypeptide-related sequence B (MICB) OTS2DVDW MICB_HUMAN Increases Expression [33]
MHC class I polypeptide-related sequence A (MICA) OTPEIEAR MICA_HUMAN Increases Expression [33]
Major histocompatibility complex class I-related gene protein (MR1) OTZU3XX7 HMR1_HUMAN Affects Expression [24]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [21]
Transcription factor SOX-17 (SOX17) OT9H4WWE SOX17_HUMAN Decreases Localization [34]
MARVEL domain-containing protein 1 (MARVELD1) OT5CPOJE MALD1_HUMAN Decreases Response To Substance [35]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Affects Response To Substance [36]
Membrane-associated progesterone receptor component 1 (PGRMC1) OTBE6WAC PGRC1_HUMAN Decreases Response To Substance [37]
RNA-binding protein 7 (RBM7) OTFIWTMF RBM7_HUMAN Affects Response To Substance [38]
Cell death regulator Aven (AVEN) OTGIN5YK AVEN_HUMAN Affects Response To Substance [38]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Increases Response To Substance [39]
Phospholipase B-like 1 (PLBD1) OTHYEB4W PLBL1_HUMAN Affects Response To Substance [38]
Securin (PTTG1) OTIMYS4W PTTG1_HUMAN Decreases Response To Substance [26]
Pleckstrin homology-like domain family A member 2 (PHLDA2) OTMV9DPP PHLA2_HUMAN Affects Response To Substance [38]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Affects Response To Substance [9]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Response To Substance [40]
Ceramide transfer protein (CERT1) OTNUCNHX CERT_HUMAN Affects Response To Substance [38]
Dual specificity protein phosphatase 3 (DUSP3) OTPJX9B4 DUS3_HUMAN Affects Response To Substance [38]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Response To Substance [41]
Pericentrin (PCNT) OTW4Z65J PCNT_HUMAN Decreases Response To Substance [37]
Coronin-1C (CORO1C) OTXDF9T3 COR1C_HUMAN Affects Response To Substance [38]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Affects Response To Substance [9]
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⏷ Show the Full List of 64 DOT(s)
Indication(s) of Mifepristone
Disease Entry ICD 11 Status REF
Cushing disease 5A70 Approved [4]
Mifepristone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [44]
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Mifepristone Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [45]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [46]
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Mifepristone Interacts with 171 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Increases ADR [47]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Expression [48]
Frizzled-9 (FZD9) OTTZ9MKK FZD9_HUMAN Increases Expression [42]
Forkhead box protein N3 (FOXN3) OTOJYJZP FOXN3_HUMAN Increases Expression [42]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2) OTKOZRZP PLOD2_HUMAN Increases Expression [42]
Actin-binding LIM protein 1 (ABLIM1) OTHXEK3E ABLM1_HUMAN Increases Expression [42]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Increases Expression [42]
Histone-lysine N-methyltransferase 2D (KMT2D) OTTVHCLY KMT2D_HUMAN Decreases Expression [42]
17-beta-hydroxysteroid dehydrogenase type 6 (HSD17B6) OTSB55D2 H17B6_HUMAN Decreases Expression [42]
Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) OT8L6EGI BCAT2_HUMAN Decreases Expression [42]
Calpain-5 (CAPN5) OTQ8QM7K CAN5_HUMAN Decreases Expression [42]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Decreases Expression [42]
Septin-4 (SEPTIN4) OTD16B30 SEPT4_HUMAN Decreases Expression [42]
Cationic amino acid transporter 4 (SLC7A4) OTAVC6QS CTR4_HUMAN Decreases Expression [42]
Proline dehydrogenase 1, mitochondrial (PRODH) OT7SQ1C7 PROD_HUMAN Decreases Expression [42]
Synaptogyrin-1 (SYNGR1) OT0MBUK5 SNG1_HUMAN Decreases Expression [42]
Frizzled-6 (FZD6) OTBCPII8 FZD6_HUMAN Increases Expression [42]
Sushi repeat-containing protein SRPX2 (SRPX2) OT6A63TX SRPX2_HUMAN Increases Expression [42]
Sorting nexin-2 (SNX2) OT889MQA SNX2_HUMAN Increases Expression [42]
P antigen family member 4 (PAGE4) OT2VLWT0 PAGE4_HUMAN Decreases Expression [42]
Slit homolog 3 protein (SLIT3) OTU8MKEU SLIT3_HUMAN Decreases Expression [42]
Large neutral amino acids transporter small subunit 3 (SLC43A1) OTQJQY3S LAT3_HUMAN Decreases Expression [42]
Solute carrier family 22 member 3 (SLC22A3) OTQYGVXX S22A3_HUMAN Decreases Expression [42]
E3 ubiquitin-protein ligase NEURL1 (NEURL1) OT2C4P70 NEUL1_HUMAN Increases Expression [42]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Decreases Expression [42]
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3) OTDSN5XF B3GA3_HUMAN Decreases Expression [42]
Myelin protein zero-like protein 1 (MPZL1) OTJSUUHR MPZL1_HUMAN Decreases Expression [42]
Supervillin (SVIL) OTWQQ1WK SVIL_HUMAN Increases Expression [42]
Protein LDOC1 (LDOC1) OTWZH4O9 LDOC1_HUMAN Decreases Expression [42]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [42]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Decreases Expression [42]
Apolipoprotein C-I (APOC1) OTA58CED APOC1_HUMAN Decreases Expression [42]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [42]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Decreases Expression [42]
Protein S100-A6 (S100A6) OTHHPZQ8 S10A6_HUMAN Decreases Expression [42]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [42]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [42]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [42]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [42]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Decreases Expression [42]
Glutathione S-transferase theta-2 (GSTT2) OTANW3TJ GST2_HUMAN Decreases Expression [42]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [42]
Pyruvate carboxylase, mitochondrial (PC) OT6O0V51 PYC_HUMAN Decreases Expression [42]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Decreases Expression [42]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [42]
HLA class II histocompatibility antigen, DO beta chain (HLA-DOB) OTKADDUB DOB_HUMAN Decreases Expression [42]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Decreases Expression [42]
Fumarylacetoacetase (FAH) OTGZA1YR FAAA_HUMAN Decreases Expression [42]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) OT2D9DOV TNR1A_HUMAN Increases Expression [42]
Fibulin-1 (FBLN1) OT5MHHOP FBLN1_HUMAN Decreases Expression [42]
Laminin subunit alpha-2 (LAMA2) OTFROQWE LAMA2_HUMAN Decreases Expression [42]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [42]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [42]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Decreases Expression [42]
Collagen alpha-5(IV) chain (COL4A5) OTHG60RE CO4A5_HUMAN Decreases Expression [42]
ER lumen protein-retaining receptor 2 (KDELR2) OT9QW7Q0 ERD22_HUMAN Increases Expression [42]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [42]
Prostaglandin-H2 D-isomerase (PTGDS) OT71NN7C PTGDS_HUMAN Decreases Expression [42]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Increases Expression [42]
C-X-C motif chemokine 5 (CXCL5) OTZOUPCA CXCL5_HUMAN Increases Expression [42]
Small ribosomal subunit protein eS10 (RPS10) OTE3VSAH RS10_HUMAN Increases Expression [42]
Microtubule-associated protein 1B (MAP1B) OTVXW089 MAP1B_HUMAN Increases Expression [42]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Increases Expression [42]
Heat shock 70 kDa protein 13 (HSPA13) OTYXMC4G HSP13_HUMAN Increases Expression [42]
DNA polymerase delta subunit 2 (POLD2) OTBNASP6 DPOD2_HUMAN Decreases Expression [42]
MARCKS-related protein (MARCKSL1) OT13J2FM MRP_HUMAN Increases Expression [42]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [42]
ADP-ribosylation factor-like protein 4D (ARL4D) OTG5I3KU ARL4D_HUMAN Decreases Expression [42]
RNA-binding protein Nova-1 (NOVA1) OT6A9KHY NOVA1_HUMAN Increases Expression [42]
Lumican (LUM) OTSRC874 LUM_HUMAN Increases Expression [42]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Increases Expression [42]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Expression [42]
Sestrin-3 (SESN3) OTJRY1Y5 SESN3_HUMAN Increases Expression [42]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Decreases Expression [42]
Ras-related protein Rap-1b (RAP1B) OTHEIIMM RAP1B_HUMAN Increases Expression [42]
26S proteasome regulatory subunit 10B (PSMC6) OTG8997V PRS10_HUMAN Increases Expression [42]
Large ribosomal subunit protein eL39 (RPL39) OTL8TZHQ RL39_HUMAN Increases Expression [42]
Contactin-associated protein 1 (CNTNAP1) OT5Y03EU CNTP1_HUMAN Decreases Expression [42]
Sushi repeat-containing protein SRPX (SRPX) OT5B9LXS SRPX_HUMAN Decreases Expression [42]
C-C motif chemokine 8 (CCL8) OTCTWYN8 CCL8_HUMAN Decreases Expression [42]
Rho-related GTP-binding protein RhoG (RHOG) OTJ7J1WA RHOG_HUMAN Decreases Expression [42]
Small EDRK-rich factor 2 (SERF2) OTZQDYCZ SERF2_HUMAN Increases Expression [42]
Norrin (NDP) OTGDJ4US NDP_HUMAN Decreases Expression [42]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A) OTSK5GFC P2R3A_HUMAN Increases Expression [42]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Increases Expression [42]
Sperm-associated antigen 1 (SPAG1) OT29JZKW SPAG1_HUMAN Increases Expression [42]
ATP-binding cassette sub-family C member 8 (ABCC8) OTCWQ54I ABCC8_HUMAN Decreases Expression [42]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1) OTTA5C3U AIMP1_HUMAN Increases Expression [42]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Increases Expression [42]
Metastasis-associated protein MTA1 (MTA1) OTBHW3S9 MTA1_HUMAN Decreases Expression [42]
Laminin subunit gamma-2 (LAMC2) OTJMTM72 LAMC2_HUMAN Increases Expression [42]
Collagen alpha-6(IV) chain (COL4A6) OTUREU5Z CO4A6_HUMAN Decreases Expression [42]
Interleukin-13 receptor subunit alpha-2 (IL13RA2) OTPC2G0X I13R2_HUMAN Increases Expression [42]
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) OT536XAV AR6P1_HUMAN Increases Expression [42]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK) OTAP5AT3 PTPRK_HUMAN Increases Expression [42]
Monocyte to macrophage differentiation factor (MMD) OTB5I4OC PAQRB_HUMAN Increases Expression [42]
TSC22 domain family protein 1 (TSC22D1) OTN4GFWD T22D1_HUMAN Increases Expression [42]
Adipogenesis regulatory factor (ADIRF) OTTJP8D4 ADIRF_HUMAN Decreases Expression [42]
Mitogen-activated protein kinase 6 (MAPK6) OTDDNF3Q MK06_HUMAN Increases Expression [42]
Laminin subunit alpha-3 (LAMA3) OTFME7HT LAMA3_HUMAN Decreases Expression [42]
Centrosomal protein kizuna (KIZ) OT5VCKSM KIZ_HUMAN Increases Expression [42]
Carboxypeptidase Z (CPZ) OT5HUR28 CBPZ_HUMAN Increases Expression [42]
F-box only protein 46 (FBXO46) OT773EPG FBX46_HUMAN Decreases Expression [42]
Plexin domain-containing protein 2 (PLXDC2) OTS1FUV6 PXDC2_HUMAN Increases Expression [42]
Acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase (B3GNT6) OTAX8BNJ B3GN6_HUMAN Decreases Expression [42]
Kinesin-like protein KIF27 (KIF27) OTV70I2Q KIF27_HUMAN Increases Expression [42]
Osteopetrosis-associated transmembrane protein 1 (OSTM1) OTKNJDH7 OSTM1_HUMAN Increases Expression [42]
Membrane progestin receptor alpha (PAQR7) OTIWX5AM PAQR7_HUMAN Decreases Expression [42]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [42]
RB1-inducible coiled-coil protein 1 (RB1CC1) OTZK8PFX RBCC1_HUMAN Increases Expression [42]
Protein phosphatase 1 regulatory subunit 1C (PPP1R1C) OTVH6BND PPR1C_HUMAN Increases Expression [42]
Kelch-like protein 6 (KLHL6) OTLDECOX KLHL6_HUMAN Increases Expression [42]
C-type lectin domain family 2 member B (CLEC2B) OT0W0M0L CLC2B_HUMAN Increases Expression [42]
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8) OTX1DWEF DHB8_HUMAN Decreases Expression [42]
Tribbles homolog 2 (TRIB2) OTHSX3MX TRIB2_HUMAN Increases Expression [42]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Increases Expression [42]
Stathmin-2 (STMN2) OT0FUHLH STMN2_HUMAN Increases Expression [42]
Seipin (BSCL2) OT73V6Y4 BSCL2_HUMAN Decreases Expression [42]
Receptor expression-enhancing protein 6 (REEP6) OTY4FPO8 REEP6_HUMAN Decreases Expression [42]
Mannose-1-phosphate guanyltransferase alpha (GMPPA) OTADC03N GMPPA_HUMAN Decreases Expression [42]
Mastermind-like protein 3 (MAML3) OTZFV53Z MAML3_HUMAN Increases Expression [42]
Translocation protein SEC62 (SEC62) OTCWEL5F SEC62_HUMAN Increases Expression [42]
Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) OTVFRL8G TI17A_HUMAN Increases Expression [42]
C-C motif chemokine 13 (CCL13) OTNX0JD0 CCL13_HUMAN Decreases Expression [42]
SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1) OTQW6R3Z SGIP1_HUMAN Increases Expression [42]
Receptor expression-enhancing protein 2 (REEP2) OTPCRA5O REEP2_HUMAN Decreases Expression [42]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [42]
Complement C1q tumor necrosis factor-related protein 6 (C1QTNF6) OT57EPQC C1QT6_HUMAN Increases Expression [42]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2) OTVSFHTL CRLD2_HUMAN Decreases Expression [42]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [42]
Netrin-4 (NTN4) OTDRRMP3 NET4_HUMAN Increases Expression [42]
Endothelial cell-specific molecule 1 (ESM1) OT331Y8V ESM1_HUMAN Increases Expression [42]
Exosome complex component RRP46 (EXOSC5) OTADUQ7H EXOS5_HUMAN Decreases Expression [42]
Protein reprimo (RPRM) OTNNBAS1 RPRM_HUMAN Decreases Expression [42]
E3 ubiquitin-protein ligase RNF146 (RNF146) OTE4CO7E RN146_HUMAN Increases Expression [42]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Decreases Expression [42]
CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6) OT70T27A CKLF6_HUMAN Increases Expression [42]
Ankyrin repeat domain-containing protein 10 (ANKRD10) OTIZ2VK8 ANR10_HUMAN Increases Expression [42]
LIM and cysteine-rich domains protein 1 (LMCD1) OT3AWE8O LMCD1_HUMAN Decreases Expression [42]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Increases Expression [42]
Alpha-catulin (CTNNAL1) OTESJ6JD CTNL1_HUMAN Increases Expression [42]
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2) OT9PBQVT SIA7B_HUMAN Increases Expression [42]
Polypyrimidine tract-binding protein 2 (PTBP2) OTF4S7NE PTBP2_HUMAN Increases Expression [42]
Frizzled-4 (FZD4) OTGLZIE0 FZD4_HUMAN Increases Expression [42]
Lysosomal thioesterase PPT2 (PPT2) OTD5VJ9A PPT2_HUMAN Increases Expression [42]
Sorting nexin-12 (SNX12) OTARRSWB SNX12_HUMAN Decreases Expression [42]
HIG1 domain family member 1A, mitochondrial (HIGD1A) OTS351DV HIG1A_HUMAN Increases Expression [42]
Band 4.1-like protein 3 (EPB41L3) OTS6CHG2 E41L3_HUMAN Increases Expression [42]
Long-chain fatty acid transport protein 5 (SLC27A5) OT4OK511 S27A5_HUMAN Decreases Expression [42]
Axin-2 (AXIN2) OTRMGQNU AXIN2_HUMAN Increases Expression [42]
Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) OTYOTM2B NUBP2_HUMAN Increases Expression [42]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Decreases Expression [42]
Calcineurin-binding protein cabin-1 (CABIN1) OT4G5CIK CABIN_HUMAN Increases Expression [42]
SEC23-interacting protein (SEC23IP) OTTZ0FXP S23IP_HUMAN Increases Expression [42]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [49]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [50]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Decreases Expression [51]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [52]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Activity [53]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [54]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [55]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [56]
Forkhead box protein L2 (FOXL2) OTFRQUYL FOXL2_HUMAN Increases Expression [55]
Neutrophil defensin 1 (DEFA1) OT5N1B9B DEF1_HUMAN Decreases Expression [51]
Neutrophil defensin 3 (DEFA3) OTO3N8E1 DEF3_HUMAN Decreases Expression [51]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [57]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Increases Expression [58]
Progesterone-induced-blocking factor 1 (PIBF1) OTCBT1A1 PIBF1_HUMAN Decreases Expression [51]
Interleukin-1 receptor-associated kinase 4 (IRAK4) OT9JTJWC IRAK4_HUMAN Decreases Expression [51]
Semaphorin-3B (SEMA3B) OTCZCPMS SEM3B_HUMAN Increases Response To Substance [59]
Semaphorin-3F (SEMA3F) OTQFMS8S SEM3F_HUMAN Increases Response To Substance [59]
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⏷ Show the Full List of 171 DOT(s)

References

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