Details of the Drug Combination

General Information of Drug Combination (ID: DCWQNXU)

• Drug Combination Name: SB 228357 + MK-4815
• Indication: DD2; Status: Investigative [1]
• Component Drugs:
  SB 228357 (DMKA8R4): Small molecular drug
  MK-4815 (DMT9K74): N.A.
• High-throughput Screening Result:
  Testing Cell Line: DD2
  Zero Interaction Potency (ZIP) Score: 4.044
  Bliss Independence Score: 6.792
  Loewe Additivity Score: 3.711
  LHighest Single Agent (HSA) Score: 4.533

Molecular Interaction Atlas of This Drug Combination

Indication(s) of SB 228357

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[2]

SB 228357 Interacts with 3 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
5-HT 2B receptor (HTR2B)	TT0K1SC	5HT2B_HUMAN	Antagonist	[4]
5-HT 2A receptor (HTR2A)	TTJQOD7	5HT2A_HUMAN	Antagonist	[4]
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Antagonist	[4]

Indication(s) of MK-4815

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Investigative	[3]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Hepatoblastoma	DC0JQD2	HB3	Investigative	[5]

References

• [1] CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 192).
• [3] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [4] Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34.
• [5] CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976