Details of the Drug Combination

General Information of Drug Combination (ID: DCWU00A)

Drug Combination Name

TEM PMID28870136-Compound-43

Indication

Disease Entry	Status	REF
Renal cell carcinoma	Investigative	[1]

Component Drugs

TEM DMLNFWU

PMID28870136-Compound-43 DMWGV8N

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: SN12C

Zero Interaction Potency (ZIP) Score: 0.36

Bliss Independence Score: 5.99

Loewe Additivity Score: 3.17

LHighest Single Agent (HSA) Score: 3.2

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of TEM

Disease Entry	ICD 11	Status	REF
Postherpetic neuralgia	1E91.5	Phase 2	[2]

PMID28870136-Compound-43 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Ecto-5'-nucleotidase (CD73)	TTK0O6Y	5NTD_HUMAN	Inhibitor	[3]
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Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
High grade ovarian serous adenocarcinoma	DCDR3LU	OVCAR-5	Investigative	[4]
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References

1	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125966
2	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3	Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
4	CheMBL Affinity Phenotypic Cellular Interaction Assay ID: CHEMBL1125976