Details of the Drug Combination

General Information of Drug Combination (ID: DCZ44WW)

Drug Combination Name
Bisacodyl Mannitol
Indication
Disease Entry Status REF
Bowel Preparation Phase 4 [1]
Component Drugs Bisacodyl   DM178H9 Mannitol   DMSCDY9
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Bisacodyl
Disease Entry ICD 11 Status REF
Constipation DD91.1 Approved [2]
Indication(s) of Mannitol
Disease Entry ICD 11 Status REF
Bronchiectasis CA24 Approved [3]
Cerebral edema 8D60.1 Approved [4]
Cystic fibrosis CA25 Approved [4]
Edema MG29 Approved [4]
Ocular hypertension 9C61.01 Approved [4]
Pseudotumor cerebri N.A. Approved [4]
Renal failure GB60-GB6Z Approved [3]
Mannitol Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aspergillus Mannitol 2-dehydrogenase (Asperg M2DH) TTTX5M8 M2DH_ASPFU Activator [5]
Aspergillus Mannitol-1-phosphate 5-dehydrogenase (Asperg mpdA) TTV0PE2 MTLD_ASPFU Activator [5]
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Mannitol Interacts with 9 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [6]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [7]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Increases Expression [8]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [9]
Tumor protein D52 (TPD52) OTPKSK43 TPD52_HUMAN Decreases Expression [9]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [9]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Increases ADR [10]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases ADR [10]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Affects Response To Substance [11]
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⏷ Show the Full List of 9 DOT(s)

References

1 ClinicalTrials.gov (NCT02386449) A Study Comparing Picoprep With Mannitol and Bisacodyl for Colon Cleansing in Preparation for Colonoscopy
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016080.
4 Mannitol FDA Label
5 Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies o... Chem Biol Interact. 2009 Mar 16;178(1-3):274-82.
6 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
7 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
8 [Plasma levels of atrial natriuretic factor (ANF) in the stroke patients after glycerol and mannitol infusion]. Zhonghua Yi Xue Za Zhi (Taipei). 1990 Aug;46(2):86-90.
9 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
10 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
11 Differential expression and roles of volume-activated chloride channels in control of growth of normal and cancerous nasopharyngeal epithelial cells. Biochem Pharmacol. 2012 Feb 1;83(3):324-34. doi: 10.1016/j.bcp.2011.11.007. Epub 2011 Nov 18.