Details of the Drug Combination

General Information of Drug Combination (ID: DCZLQOK)

Drug Combination Name
Tindamax Azithromycin
Indication
Disease Entry Status REF
Urethritis Phase 1 [1]
Component Drugs Tindamax   DM3OWT4 Azithromycin   DMS6UOE
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL is unavailable

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Tindamax
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [2]
Bacterial vaginosis MF3A Approved [3]
Trichomoniasis N.A. Approved [4]
Giardiasis N.A. Investigative [5]
Tindamax Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [9]
Nitroreductase (NTR) DEAN5EW NFSB_ENTCL Metabolism [10]
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Tindamax Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [11]
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Indication(s) of Azithromycin
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis N.A. Approved [6]
Bronchitis CA20 Approved [7]
Chancroid N.A. Approved [6]
Mycoplasma pneumoniae pneumonia N.A. Approved [6]
Staphylococcus aureus infection N.A. Approved [6]
Streptococcal pneumonia N.A. Approved [6]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [8]
Pneumonia caused by chlamydia N.A. Investigative [6]

References

1 ClinicalTrials.gov (NCT00322465) NGU: Doxycycline (Plus or Minus Tinidazole) Versus Azithromycin (Plus or Minus Tinidazole)
2 2004 approvals: the demise of the blockbuster. Nat Rev Drug Discov. 2005 Feb;4(2):93-4.
3 Tinidazole. 2021 Mar 17. Drugs and Lactation Database (LactMed?) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006C.
4 Tinidazole (Tindamax)--a new option for treatment of bacterial vaginosis. Med Lett Drugs Ther. 2007 Sep 10;49(1269):73-4.
5 Tinidazole (Tindamax) - a new anti-protozoal drug. Med Lett Drugs Ther. 2004 Aug 30;46(1190):70-2.
6 Azithromycin FDA Label
7 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 065511.
8 ClinicalTrials.gov (NCT04332107) Azithromycin for COVID-19 Treatment in Outpatients Nationwide. U.S. National Institutes of Health.
9 FDA label of Tinidazole. The 2020 official website of the U.S. Food and Drug Administration.
10 Overexpression, isotopic labeling, and spectral characterization of Enterobacter cloacae nitroreductase. Protein Expr Purif. 1998 Jun;13(1):53-60.
11 Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.