General Information of Drug Combination (ID: DCZWEU0)

Drug Combination Name
Olanzapine Probenecid
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Olanzapine   DMPFN6Y Probenecid   DMMFWOJ
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: KBM-7
Zero Interaction Potency (ZIP) Score: 39.15
Bliss Independence Score: 39.15
Loewe Additivity Score: 55.87
LHighest Single Agent (HSA) Score: 55.88

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Olanzapine
Disease Entry ICD 11 Status REF
Bipolar depression N.A. Approved [2]
Major depressive disorder 6A70.3 Approved [2]
Schizoaffective disorder 6A21 Approved [2]
Schizophrenia 6A20 Approved [3]
Olanzapine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Agonist [7]
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Olanzapine Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]
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Olanzapine Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [9]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [10]
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Olanzapine Interacts with 63 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Activity [11]
D(2) dopamine receptor (DRD2) OTBLXKEG DRD2_HUMAN Increases Response To Substance [12]
Lathosterol oxidase (SC5D) OT41KMW4 SC5D_HUMAN Increases Expression [13]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [13]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Increases Expression [13]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [13]
Long-chain fatty acid transport protein 2 (SLC27A2) OT7JEG5F S27A2_HUMAN Increases Expression [14]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [15]
Ceruloplasmin (CP) OTM8JE4Y CERU_HUMAN Affects Phosphorylation [16]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Affects Phosphorylation [16]
Complement factor B (CFB) OTZITNEJ CFAB_HUMAN Affects Phosphorylation [16]
Alpha-1-antichymotrypsin (SERPINA3) OT9BP2S0 AACT_HUMAN Increases Phosphorylation [16]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Affects Phosphorylation [16]
Complement C3 (C3) OTCH5GS0 CO3_HUMAN Affects Phosphorylation [16]
Complement C5 (C5) OTSL3OIC CO5_HUMAN Affects Phosphorylation [16]
Kininogen-1 (KNG1) OT4X9LDE KNG1_HUMAN Affects Phosphorylation [16]
Prolactin (PRL) OTWFQGX7 PRL_HUMAN Increases Expression [17]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [18]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Phosphorylation [16]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Increases Phosphorylation [16]
Complement component C9 (C9) OT7I5FDX CO9_HUMAN Affects Phosphorylation [16]
Beta-2-glycoprotein 1 (APOH) OTFMUX6O APOH_HUMAN Affects Phosphorylation [16]
Fibronectin (FN1) OTB5ZN4Q FINC_HUMAN Affects Phosphorylation [16]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Phosphorylation [16]
Vitamin D-binding protein (GC) OTWS63BY VTDB_HUMAN Affects Phosphorylation [16]
Hemopexin (HPX) OT14T7Q1 HEMO_HUMAN Affects Phosphorylation [16]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Increases Phosphorylation [16]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Affects Phosphorylation [16]
Alpha-1B-glycoprotein (A1BG) OTFVUGNQ A1BG_HUMAN Affects Phosphorylation [16]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Decreases Expression [19]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [20]
Plasma protease C1 inhibitor (SERPING1) OT6CVN45 IC1_HUMAN Affects Phosphorylation [16]
Apolipoprotein A-IV (APOA4) OT466POQ APOA4_HUMAN Affects Phosphorylation [16]
Fatty acid-binding protein, liver (FABP1) OTR34ETM FABPL_HUMAN Increases Expression [14]
Complement factor H (CFH) OTAGKQTJ CFAH_HUMAN Decreases Phosphorylation [16]
Complement C4-A (C4A) OTXMOYXU CO4A_HUMAN Decreases Phosphorylation [16]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Affects Phosphorylation [16]
Muscarinic acetylcholine receptor M1 (CHRM1) OTKW3E6B ACM1_HUMAN Affects Binding [21]
Complement component C6 (C6) OTCKR304 CO6_HUMAN Affects Phosphorylation [16]
Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4) OTJZG0LD GLUT4_HUMAN Increases Expression [22]
Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2) OTG3WBBE ITIH2_HUMAN Affects Phosphorylation [16]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Expression [23]
5-hydroxytryptamine receptor 2A (HTR2A) OTWXJX0M 5HT2A_HUMAN Affects Binding [21]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [24]
Histamine H1 receptor (HRH1) OT8F9FV6 HRH1_HUMAN Affects Binding [21]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Increases Expression [18]
Pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1) OTNBHULA PACR_HUMAN Affects Expression [6]
Afamin (AFM) OTPOR8IO AFAM_HUMAN Affects Phosphorylation [16]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Expression [24]
5-hydroxytryptamine receptor 6 (HTR6) OT8GTDDY 5HT6R_HUMAN Affects Binding [21]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [25]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Expression [20]
Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) OT460OO1 ITIH4_HUMAN Affects Phosphorylation [16]
Long-chain fatty acid transport protein 5 (SLC27A5) OT4OK511 S27A5_HUMAN Increases Expression [14]
D(3) dopamine receptor (DRD3) OT0OFFKB DRD3_HUMAN Increases ADR [26]
5-hydroxytryptamine receptor 1A (HTR1A) OT38K9MK 5HT1A_HUMAN Increases Response [27]
5-hydroxytryptamine receptor 2C (HTR2C) OT6H8DE0 5HT2C_HUMAN Increases Response To Substance [28]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Response To Substance [29]
Aquaporin-4 (AQP4) OTA9MYD5 AQP4_HUMAN Increases Response To Substance [30]
D(4) dopamine receptor (DRD4) OTAJTO7N DRD4_HUMAN Increases ADR [26]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases ADR [26]
Methylenetetrahydrofolate reductase (MTHFR) OTUBJSR7 MTHR_HUMAN Affects Response To Substance [31]
Synaptosomal-associated protein 25 (SNAP25) OTUIQ81Q SNP25_HUMAN Affects Response To Substance [32]
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⏷ Show the Full List of 63 DOT(s)
Indication(s) of Probenecid
Disease Entry ICD 11 Status REF
Acute gonococcal cervicitis N.A. Approved [4]
Gout FA25 Approved [5]
Hyperuricaemia 5C55.Y Approved [5]
Probenecid Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Solute carrier family 22 member 8 (SLC22A8) TTTQR47 S22A8_HUMAN Blocker [34]
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Probenecid Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [35]
Organic anion transporting polypeptide 1A2 (SLCO1A2) DTE2B1D SO1A2_HUMAN Substrate [36]
Monocarboxylate transporter 6 (SLC16A5) DT3I124 MOT6_HUMAN Substrate [37]
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Probenecid Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [38]
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Probenecid Interacts with 13 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Activity [39]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Activity [40]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Expression [41]
Taste receptor type 2 member 38 (TAS2R38) OTX5MM36 T2R38_HUMAN Decreases Activity [42]
Taste receptor type 2 member 43 (TAS2R43) OT70V8MZ T2R43_HUMAN Decreases Activity [42]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [43]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [43]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [44]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [44]
Sodium-coupled monocarboxylate transporter 1 (SLC5A8) OTA0WELF SC5A8_HUMAN Decreases Activity [45]
Organic anion transporter 3 (SLC22A8) OT8BY933 S22A8_HUMAN Decreases Expression [46]
Solute carrier family 22 member 12 (SLC22A12) OT72ZAWS S22AC_HUMAN Affects Activity [47]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [48]
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⏷ Show the Full List of 13 DOT(s)

References

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2 Olanzapine FDA Label
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