General Information of This Drug (ID: DM05DR0)

Drug Name
Sitosterol   DM05DR0
Synonyms
BETA-SITOSTEROL; Sitosterol; 83-46-5; Cupreol; Quebrachol; 22,23-Dihydrostigmasterol; Triastonal; Azuprostat; Rhamnol; Cinchol; Harzol; beta-Sitosterin; alpha-Dihydrofucosterol; Nimbosterol; Stigmast-5-en-3beta-ol; B-Sitosterol; Sito-Lande; (-)-beta-Sitosterol; (3beta)-Stigmast-5-en-3-ol; .beta.-Sitosterol; Angelicin (steroid); 24alpha-Ethylcholesterol; a-Dihydrofucosterol; .beta.-Sitosterin; Phytosterol; Prostasal; NSC8096; SITOSTEROL, BETA; (24R)-Stigmast-5-en-3beta-ol; .alpha.-Dihydrofucosterol; (24R)-Ethylcholest-5-en-3beta-ol
Indication
Disease Entry ICD 11 Status REF
Hyperlipidaemia 5C80 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Eltanexor oral + Sitosterol DCD4WJJ Eltanexor oral Hepatoblastoma (Cell Line: HB3) [2]
Sitosterol + GSK2126458 DCQIJRH GSK2126458 DD2 (Cell Line: DD2) [3]
Sitosterol + Methylene blue DCGN3E9 Methylene blue DD2 (Cell Line: DD2) [3]
Sitosterol + Midostaurin DC0A0SI Midostaurin Hepatoblastoma (Cell Line: HB3) [2]
Sitosterol + Piperaquine DCOJHXV Piperaquine Hepatoblastoma (Cell Line: HB3) [2]
Sitosterol + Mefloquine DCI36WZ Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
TG100-115 + Sitosterol DCXOKDB TG100-115 Hepatoblastoma (Cell Line: HB3) [3]
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⏷ Show the Full List of 7 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.