Details of the Drug Combinations

General Information of This Drug (ID: DM0FB1J)

Drug Name

Sertraline DM0FB1J

Synonyms

Lustral; SRE; Sertralina; Sertralinum; Sertralina [Spanish]; Sertraline [Zoloft]; Sertralinum [Latin]; CP 51974; Cp 51974; Apo-Sertraline; Lustral (TN); Sertraline (INN); Sertraline (Zoloft); Sertraline [INN:BAN]; Zoloft (TN); (+)-Sertraline; (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine; (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine; (1S-cis)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine

Indication

Disease Entry	ICD 11	Status	REF
Coronary heart disease	BA80.Z	Approved	[1]
Depression	6A70-6A7Z	Approved	[2]
Epilepsy	8A60-8A68	Approved	[1]
Obsessive compulsive disorder	6B20	Approved	[1]
Panic disorder	6B01	Approved	[1]
Post-traumatic stress disorder	6B40	Approved	[1]
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Therapeutic Class

Antidepressants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

61 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acarbose + Sertraline	DCOYX5Z	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acetazolamide + Sertraline	DCFOOX7	Acetazolamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Allopurinol + Sertraline	DCP0QMP	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Auranofin + Sertraline	DCQTPGP	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BIO-300 + Sertraline	DCVW38R	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Sertraline	DCYGSY8	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Sertraline	DC1QWYO	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorambucil + Sertraline	DCYPC7C	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chloroquine + Sertraline	DCY7SBL	Chloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ciprofibrate + Sertraline	DCTTQN1	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Crotamiton + Sertraline	DCPQXM4	Crotamiton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Daidzin + Sertraline	DCCHNOP	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diethylcarbamazine + Sertraline	DC8C19B	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Sertraline	DC9VDUW	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dronedarone + Sertraline	DCF9T2P	Dronedarone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Everolimus + Sertraline	DCO2I3F	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Sertraline	DCGGC9H	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Gefitinib + Sertraline	DCI0CPI	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ginsenoside Rb1 + Sertraline	DC4C02P	Ginsenoside Rb1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hydralazine + Sertraline	DC11I9L	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Idarubicin + Sertraline	DCGSSUX	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Itraconazole + Sertraline	DCUK556	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
JZL195 + Sertraline	DC90REG	JZL195	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Sertraline	DCE7YET	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mefloquine + Sertraline	DCCA7DP	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Sertraline	DCGV1TC	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylene blue + Sertraline	DCTZ4QW	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + Sertraline	DC5FR4Y	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Sertraline	DCSV2SA	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Niclosamide + Sertraline	DCI5OHM	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + Sertraline	DC4AKT1	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PHA-739358 + Sertraline	DCKWOXA	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phensuximide + Sertraline	DCI4BBL	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pinacidil + Sertraline	DCAKMOY	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Sertraline	DC9F88B	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Quinine + Sertraline	DCMX47C	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Mebutamate	DCRTXZR	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Tacrine	DCK4LB9	Tacrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Miglustat	DCO6CTL	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Vinblastine	DC6QM5B	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Acitretin	DCHYKIR	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Methylergonovine	DCPLHTT	Methylergonovine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Arfolitixorin	DC9N6GU	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Tiagabine	DCM86OY	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Oseltamivir	DCB8BZH	Oseltamivir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Artemisinin	DCNES36	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Clascoterone	DCX37SE	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Trimethobenzamide	DC446YW	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	DC4LPT0	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Leflunomide	DCD8EMV	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Bumetanide	DCZZ2ES	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Desoxycorticosterone pivalate	DCTK4WE	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Hyodeoxycholic acid	DCMUFWX	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Spironolactone	DCVHPX1	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Silver sulfadiazine	DCTBHAS	Silver sulfadiazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Vorinostat	DCDI2QR	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sertraline + Cytarabine	DCV2V1M	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Triapine + Sertraline	DCUXRT8	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trifluoperazine + Sertraline	DCQT3VK	Trifluoperazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trihexyphenidyl + Sertraline	DC10TN1	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
VR-776 + Sertraline	DC2C3GU	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
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⏷ Show the Full List of 61 DrugCom(s)

22 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Sertraline + Riluzole	DCEESEW	Riluzole	Major Depressive Disorder	[5]
Sertraline + Levetiracetam	DCHOOFD	Levetiracetam	Obsessive-Compulsive Disorder	[6]
Sertraline + Liothyronine	DCIB9X3	Liothyronine	Major Depression	[7]
Sertraline + Clonazepam	DCLPQ24	Clonazepam	Social Phobia	[8]
Sertraline + Duloxetine	DCLRJHM	Duloxetine	PTSD	[9]
Sertraline + Venlafaxine	DCO3IIW	Venlafaxine	Depression	[10]
Sertraline + Edivoxetine	DCPX8P7	Edivoxetine	Major Depressive Disorder	[11]
Sertraline + Clonazepam	DCQ4GA8	Clonazepam	Panic Disorder	[12]
Sertraline + Haloperidol	DCSWTMN	Haloperidol	Affective Disorders	[13]
Sertraline + Naltrexone	DCV9XSZ	Naltrexone	Alcoholism	[14]
Sertraline + Mirtazapine	DCVN3ZI	Mirtazapine	Posttraumatic Stress Disorder	[15]
Sertraline + Ziprasidone	DCWOLJK	Ziprasidone	Social Anxiety Disorder	[16]
Sertraline + Mirtazapine	DCY0I7Y	Mirtazapine	Unipolar Major Depressive Episode	[17]
Sertraline + Olanzapine	DCYTCPM	Olanzapine	Major Depressive Disorder With Psychotic Features	[18]
Sertraline + Acetylcysteine	DCANQ6J	Acetylcysteine	Major Depressive Disorder	[19]
Sertraline + Cytarabine	DCVDIG6	Cytarabine	Acute Myeloid Leukemia	[20]
Sertraline + Reboxetine	DCJ6NMM	Reboxetine	Bone Mineral Density Quantitative Trait Locus 7	[21]
Sertraline + Pregabalin	DC13LRL	Pregabalin	Burning Mouth Syndrome	[22]
Sertraline + Fluconazole	DCLJO0R	Fluconazole	Cryptococcosis	[23]
Sertraline + OPC-34712	DCMTBU3	OPC-34712	Post Traumatic Stress Disorder	[24]
Sertraline + Quetiapine	DC542KP	Quetiapine	Major Depressive Disorder With Psychotic Features	[25]
Sertraline + Bupropion	DCSROKR	Bupropion	Major Depressive Disorder	[26]
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⏷ Show the Full List of 22 DrugCom(s)

References

1	Sertraline FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4798).
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT01703039) Riluzole Augmentation Pilot in Depression (RAPID) Trial
6	ClinicalTrials.gov (NCT00299611) Augmentation Study of Levetiracetam in Obsessive Compulsive Disorder
7	ClinicalTrials.gov (NCT00208702) Thyroid Medication and Antidepressants for Treating Major Depression
8	ClinicalTrials.gov (NCT00282828) Improving Treatment Outcomes in Pharmacotherapy of Generalized Social Anxiety Disorder
9	ClinicalTrials.gov (NCT05930912) Psychiatric Orders in Psychoanalytic Treatment of ASD
10	ClinicalTrials.gov (NCT00043550) Treatments for Depression: Drug Versus Psychotherapy
11	ClinicalTrials.gov (NCT01250873) A Pharmacokinetic Study of the Coadministration of LY2216684 With Sertraline
12	ClinicalTrials.gov (NCT00118417) Therapies for Treatment-Resistant Panic Disorder Symptoms
13	ClinicalTrials.gov (NCT00340379) Ziprasidone vs. Sertraline/Haloperidol in Psychotic Depression
14	ClinicalTrials.gov (NCT00000451) Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
15	ClinicalTrials.gov (NCT01178671) Combined Mirtazapine and SSRI Treatment of PTSD: A Placebo-Controlled Trial
16	ClinicalTrials.gov (NCT00215150) Geodon for the Treatment of Refractory Social Anxiety Disorder
17	ClinicalTrials.gov (NCT01109693) Strategic Use of New Generation Antidepressants for Depression
18	ClinicalTrials.gov (NCT00056472) Study of Pharmacotherapy of Psychotic Depression
19	ClinicalTrials.gov (NCT02269540) A New Treatment Approach for Major Depressive Disorder Based Upon Targeting Monoamine Oxidase A (MAO-A)
20	ClinicalTrials.gov (NCT02891278) Sertraline and Cytosine Arabinoside in Adults With Relapsed and Refractory AML
21	ClinicalTrials.gov (NCT02179268) Antidepressants and Bone Mineral Density
22	ClinicalTrials.gov (NCT06025474) Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome
23	ClinicalTrials.gov (NCT03002012) Cryptococcal Antigen Screening Plus Sertraline
24	ClinicalTrials.gov (NCT04124614) Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSD
25	ClinicalTrials.gov (NCT00955474) Seroquel Alone Versus Seroquel With an SSRI for Depression With Psychotic Symptoms
26	ClinicalTrials.gov (NCT05537584) SMART Trial to Predict Anhedonia Response to Antidepressant Treatment