Details of the Drug Combinations

General Information of This Drug (ID: DM0JXBK)

Drug Name
DZNep   DM0JXBK
Synonyms 3-deazaneplanocin A
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

16 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Abexinostat + DZNep DCS2HYP Abexinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Afatinib + DZNep DC3GYRB Afatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Apilimod + DZNep DCCQ66I Apilimod Lymphoid neoplasm (Cell Line: Mak) [2]
Colchicine + DZNep DCTXM9H Colchicine Lymphoid neoplasm (Cell Line: Mak) [2]
DZNep + Trametinib DC5Q9M8 Trametinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
DZNep + Panobinostat DCE6Y1D Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
DZNep + Methotrexate DCBFWSQ Methotrexate Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
DZNep + Apilimod DCN6AWT Apilimod Lymphoid neoplasm (Cell Line: Mak) [2]
DZNep + Mebendazole DCOH9YM Mebendazole Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
DZNep + THZ1 DCNOQJQ THZ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
DZNep + Colchicine DCU492I Colchicine Lymphoid neoplasm (Cell Line: Mak) [2]
Mizoribine + DZNep DC6I55S Mizoribine Lymphoid neoplasm (Cell Line: Mak) [2]
Omacetaxine mepesuccinate + DZNep DC197UP Omacetaxine mepesuccinate Lymphoid neoplasm (Cell Line: Mak) [2]
Ospemifene + DZNep DCNX1FO Ospemifene Lymphoid neoplasm (Cell Line: Mak) [2]
RG6046 + DZNep DC4IWM4 RG6046 Lymphoid neoplasm (Cell Line: Mak) [2]
Sunitinib malate + DZNep DCIT5Q5 Sunitinib malate Lymphoid neoplasm (Cell Line: Mak) [2]
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⏷ Show the Full List of 16 DrugCom(s)

References

1 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. Biochem Biophys Res Commun. 1986 Mar 13;135(2):688-94.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.