Details of the Drug Combinations

General Information of This Drug (ID: DM0L594)

• Drug Name: Ivabradine (DM0L594)
• Synonyms: Ivabradine; 155974-00-8; Procoralan; Corlanor; Corlentor; UNII-3H48L0LPZQ; S 16257; S-16257; S-16257-2; S 16257-2; 3H48L0LPZQ; CHEMBL471737; CHEBI:85966; C27H36N2O5; 7,8-Dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one; S-16260-2; s16257; (S)-3-(3-(((3,4-Dimethoxybicyclo(4.2.0)octa-1,3,5-trien-7-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one; Ivabradine [INN]

Indication

Angina pectoris; ICD 11: BA40; Status: Approved [1]; Chronic heart failure; ICD 11: BD1Z; Status: Approved [2]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ivabradine + Bisoprolol	DCFNVX5	Bisoprolol	Heart Failure With Reduced Ejection Fraction	[3]
Ivabradine + Carvedilol	DCU667O	Carvedilol	Diastolic Dysfunction	[4]
Ivabradine + Atenolol	DCV2NUG	Atenolol	Mitral Stenosis	[5]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2357).
• [2] Ivabradine FDA Label
• [3] ClinicalTrials.gov (NCT03701880) Early Use of Ivabradine in Heart Failure
• [4] ClinicalTrials.gov (NCT02294292) Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and Mortality
• [5] ClinicalTrials.gov (NCT01022463) Effect of Ivabradine on Heart Rate & Effort Tolerance in Mitral Stenosis in Sinus Rhythm