Details of the Drug Combinations

General Information of This Drug (ID: DM1AGXN)

• Drug Name: Paromomycin (DM1AGXN)
• Synonyms: Aminosidin; Catenulin; Humatin; Hydroxymycin sulfate; Paramomycin Sulfate; Paromomycin I; Paromomycin sulfate Rx346208; Aminosidine, sulfate; HATT & Paromomycin; Humatin (TN); Paromomycin (INN); Paromomycin (TN); Paromomycin (complex); PA1-PA2-PA3-PA4; Human .alpha.-1-antitrypsin & Paromomyin; PAROMOMYCIN I, AMMINOSIDIN, CATENULIN, CRESTOMYCIN, MONOMYCIN A, NEOMYCIN E; (1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside; (2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(2R,3S,4R,5S)-5-[(1R,2R,3S,5R,6S)-3,5-diamino-2-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-hydroxycyclohexyl]oxy-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxyoxane-3,4-diol; O-2-Amino-2-deoxy-.alpha.-D-glucopyranosyl-(1->4)-O-[O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1->3)-.beta.D-ribofuranosyl(1->5)]-2-deoxy-D-streptamine

Indication

Amoebiasis; ICD 11: 1A36; Status: Approved [1]; Hepatic coma; ICD 11: N.A.; Status: Approved [1]; Intestinal amebiasis; ICD 11: 1A36; Status: Approved [2]

• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Paromomycin	DCC0J6W	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Armodafinil + Paromomycin	DCSTYGR	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Artemisinin + Paromomycin	DCESJVM	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BHV-0223 + Paromomycin	DC55TZU	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Paromomycin	DC5B671	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Paromomycin	DC7XEV5	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Paromomycin	DCUEYKT	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlormezanone + Paromomycin	DCDTNOT	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Paromomycin	DC60IV0	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diphenidol + Paromomycin	DCMEWXI	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Paromomycin	DC6Z8WD	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
IT-141 + Paromomycin	DCDCGA4	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Levamisole + Paromomycin	DCGRV6O	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mecamylamine + Paromomycin	DCOV45X	Mecamylamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Paromomycin	DCMDSTT	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pargyline + Paromomycin	DC2G4K6	Pargyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + PMID28460551-Compound-2	DCJXX44	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Dihydroergotamine	DCGLQVN	Dihydroergotamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Repaglinide	DC9KHHP	Repaglinide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Vinblastine	DCHMCIJ	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Triapine	DC4G69W	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Pepstatin	DCSRGRU	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + 10-hydroxycamptothecin	DC1NQD7	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Palonosetron	DCGHGBR	Palonosetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Terameprocol	DCDJ7A8	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Chlorzoxazone	DCCR41J	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Pentamidine	DCW5STI	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Arfolitixorin	DCWRYPU	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + BIO-300	DCO4Z1A	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Ibutilide	DCAT0AN	Ibutilide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Imatinib	DCO52QY	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Methylene blue	DC0GR64	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Dopamine	DCWQ7WE	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Eptifibatide	DCWVH9V	Eptifibatide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Endoxifen	DCSTHE3	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Hydralazine	DCV1Q7L	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Cisatracurium	DC38333	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Mefloquine	DC43V13	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Pizotyline	DC9R57Y	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Lacosamide	DC8L6IQ	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Auranofin	DCKAR7C	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Vorinostat	DCAG6DK	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Metaxalone	DC051KU	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Aciclovir	DCAD12T	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Cytarabine	DC5P6SO	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pramipexole + Paromomycin	DC8RNRM	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Quinine + Paromomycin	DC0ZKPA	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Rufinamide + Paromomycin	DC13PCS	Rufinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + Paromomycin	DCNIT00	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tiagabine + Paromomycin	DCF3YHU	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Topotecan + Paromomycin	DC5A3IM	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Triiodothyronine + Paromomycin	DCWRHYX	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Trimethobenzamide + Paromomycin	DCGV425	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Paromomycin + Sodium stibogluconate	DCCNH33	Sodium stibogluconate	Visceral Leishmaniasis	[5]
Paromomycin + Miltefosine	DCG5YN6	Miltefosine	Visceral Leishmaniasis	[5]

References

• [1] Paromomycin FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 064171.
• [3] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [4] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [5] ClinicalTrials.gov (NCT03129646) Miltefosine/Paromomycin Phase III Trial for Treatment of Primary Visceral Leishmaniasis (VL) Patients in Eastern Africa