Details of the Drug Combinations

General Information of This Drug (ID: DM1TMA3)

• Drug Name: Imiquimod (DM1TMA3)
• Synonyms: Aldara; Beselna; Zartra; Zyclara; Imiquimod acetate; R 837; S 26308; Aldara (TN); Aldara, Imiquimod; Beselna (TN); DZ-2636; Imiquimod [USAN:INN]; MTD-39; R-837; S-26308; TMX-101; Imiquimod (JAN/USAN/INN); 1-(2-Methylpropyl)-1H-imidazole[4,5-c]quinoline-4-amine; 1-(2-methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; 1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine; 1-isobutyl-1H-imidazo(4,5-c)quinolin-4-amine; 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine; 3M Brand of Imiquimod; 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline; 4-Amino-1-isobutyl-1H-imidazo[4,5-c]quinoline

Indication

Alopecia areata; ICD 11: ED70.2; Status: Approved [1]; Condyloma; ICD 11: 1A95; Status: Approved [1]; Glioblastoma; ICD 11: 2A00; Status: Approved [1]; Melanoma; ICD 11: 2C30; Status: Approved [1]; Skin cancer; ICD 11: 2C30-2C37; Status: Approved [2]

• Therapeutic Class: Antiviral Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Imiquimod + Cyclophosphamide	DCB99EA	Cyclophosphamide	Breast Cancer	[3]
Imiquimod + Gemcitabine	DCK4MLQ	Gemcitabine	Sarcoma	[4]
Imiquimod + Cyclophosphamide	DCKTYHC	Cyclophosphamide	Adenocarcinoma of the Prostate	[5]
Imiquimod + Doxycycline	DCLU9ZB	Doxycycline	Lymphoma, T-Cell, Cutaneous	[6]
Imiquimod + LDE225	DCAO0E8	LDE225	Basal Cell Carcinoma	[7]
Imiquimod + Ingenol mebutate	DC0H7KZ	Ingenol mebutate	Keratosis, Actinic	[8]

References

• [1] Imiquimod FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5003).
• [3] ClinicalTrials.gov (NCT01421017) Toll-like Receptor (TLR) 7 Agonist, Cyclophosphamide, and Radiotherapy for Breast Cancer With Skin Metastases
• [4] ClinicalTrials.gov (NCT01803152) Dendritic Cell Vaccine for Children and Adults With Sarcoma
• [5] ClinicalTrials.gov (NCT02234921) Pilot Study of DRibble Vaccine for Prostate Cancer Patients
• [6] ClinicalTrials.gov (NCT03116659) CTCL Directed Therapy
• [7] ClinicalTrials.gov (NCT03534947) A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma
• [8] ClinicalTrials.gov (NCT02281682) IM Versus 5-FU Versus IMI Versus MAL-PDT in Treatment of Actinic Keratosis