Details of the Drug Combinations

General Information of This Drug (ID: DM215WE)

Drug Name

MK-1439 DM215WE

Synonyms

Doravirine; 1338225-97-0; UNII-913P6LK81M; MK1439; 913P6LK81M; MK 1439

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
MK-1439 + Isoniazid	DCZBO4J	Isoniazid	Latent Tuberculosis	[2]
MK-1439 + Methadone	DCFDKCK	Methadone	Human Immunodeficiency Virus (HIV) Infection	[3]
MK-1439 + Dolutegravir	DCJ9PJA	Dolutegravir	HIV-1-infection	[4]
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References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	ClinicalTrials.gov (NCT03886701) Doravirine, Rifapentine and Isoniazid Interaction
3	ClinicalTrials.gov (NCT02715700) Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045)
4	ClinicalTrials.gov (NCT04892654) Efficacy of Doravirine + Dolutegravir Dual Therapy in the Context of Antiretroviral Therapy Switch