General Information of This Drug (ID: DM28UJG)

Drug Name
Dapagliflozin   DM28UJG
Synonyms BMS 512148; BMS-512148; BMS-512148, Dapagliflozin; Dapagliflozin (INN/USAN); 2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol
Indication
Disease Entry ICD 11 Status REF
Non-insulin dependent diabetes 5A11 Approved [1]
Type-2 diabetes 5A11 Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [3]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

32 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Dapagliflozin + Canagliflozin DCGKLRH Canagliflozin Diabetes Mellitus, Type 2 [4]
Dapagliflozin + Exenatide DC3SWDM Exenatide Evaluate Ketogenic Stress [5]
Dapagliflozin + Empagliflozin DC3Y735 Empagliflozin Diabetes Mellitus, Type 2 [6]
Dapagliflozin + Saxagliptin DC42707 Saxagliptin Type 2 Diabetes Mellitus [7]
Dapagliflozin + Valsartan DC8IHVT Valsartan Type 2 Diabetes Mellitus [8]
Dapagliflozin + Bumetanide DC979BI Bumetanide Type 2 Diabetes Mellitus [9]
Dapagliflozin + Sitagliptin DCCDZZE Sitagliptin Type 2 Diabetes Mellitus [10]
Dapagliflozin + Digoxin DCRMPFK Digoxin Type 2 Diabetes Mellitus [11]
Dapagliflozin + Warfarin DCWP81J Warfarin Type 2 Diabetes Mellitus [11]
Dapagliflozin + Gemigliptin DCP5LVS Gemigliptin Type 2 Diabetes Mellitus [12]
Dapagliflozin + DTI-015 DCSIKV8 DTI-015 Pediatric Brain Tumor [13]
Glimepiride + Dapagliflozin DCD2QOR Glimepiride Type 2 Diabetes Mellitus [10]
Metformin + Dapagliflozin DCMSNPO Metformin Type 2 Diabetes Mellitus [14]
Metformin + Dapagliflozin DCSEBNV Metformin Type 2 Diabetes [15]
Metformin + Dapagliflozin DCH96ME Metformin Type-2 diabetes [16]
Rifampicin + Dapagliflozin DCLDI8S Rifampicin Type 2 Diabetes Mellitus [17]
Simvastatin + Dapagliflozin DCU9DT5 Simvastatin Type 2 Diabetes Mellitus [8]
Dapagliflozin + Zibotentan DC8NX8F Zibotentan Chronic Kidney Disease [18]
Dapagliflozin + Mesalazine DCBY75V Mesalazine Inflammatory Bowel Diseases [19]
Dapagliflozin + Exenatide DCEBEX7 Exenatide Obesity [20]
Dapagliflozin + Fluoxetine DCYP3SH Fluoxetine Depressive Disorder [21]
Semaglutide + Dapagliflozin DCQZIFJ Semaglutide Kidney Transplant Recipients [22]
Dapagliflozin + Empagliflozin DC63T70 Empagliflozin Acute Decompensated Heart Failure [23]
Dapagliflozin + Gemigliptin DC6U4RC Gemigliptin Diabetes Mellitus, Type 2 [24]
Dapagliflozin + Sparsentan DCU77WL Sparsentan Immunoglobulin A Nephropathy [25]
Metformin + Dapagliflozin DC8L29B Metformin Type 2 Diabetes [26]
Dapagliflozin + Rosuvastatin DC5Z90K Rosuvastatin Diabetes Mellitus, Type 2 [27]
Dapagliflozin + Hydrochlorothiazide DCCWLXX Hydrochlorothiazide Urolithiasis [28]
Dapagliflozin + Vildagliptin DCRBWEF Vildagliptin Type 2 Diabetes [29]
Glibenclamide + Dapagliflozin DCIHYRW Glibenclamide Hypertension [30]
Glimepiride + Dapagliflozin DCNX2UH Glimepiride Type2 Diabetes [31]
Metformin + Dapagliflozin DC47MWP Metformin Diabetes Mellitus Type 2 [32]
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⏷ Show the Full List of 32 DrugCom(s)

References

1 Dapagliflozin FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4594).
3 Dapagliflozin in Respiratory Failure in Patients With COVID-19 (DARE-19)
4 ClinicalTrials.gov (NCT03249506) Cardiovascular Outcomes in Participants With Type 2 Diabetes Mellitus (T2DM)
5 ClinicalTrials.gov (NCT02962492) An Investigation Into the Effect of Dapagliflozin on Ketogenesis in Type 1 Diabetes
6 ClinicalTrials.gov (NCT03492580) A Study for Comparison of Canagliflozin Versus Alternative Antihyperglycemic Treatments on Risk of Heart Failure Hospitalization and Amputation for Participants With Type 2 Diabetes Mellitus and the Subpopulation With Established Cardiovascular Disease
7 ClinicalTrials.gov (NCT01662999) Drug Interaction Study of Saxagliptin in Combination With Dapagliflozin in Healthy Participants
8 ClinicalTrials.gov (NCT00839683) Pharmacokinetic Drug Interaction Study of Dapagliflozin and Valsartan or Simvastatin in Healthy Subjects
9 ClinicalTrials.gov (NCT00930865) Study to Evaluate the Potential Pharmacokinetic Interaction and Pharmacodynamic Effects on Renal Parameters of Bumetanide (1mg) and Dapagliflozin (10 mg) When Co-administered in Healthy Subjects
10 ClinicalTrials.gov (NCT00842556) Pharmacokinetic Drug Interaction Study of Dapagliflozin and Glimepiride or Sitagliptin in Healthy Subjects
11 ClinicalTrials.gov (NCT00904176) Study of the Effect of Dapagliflozin on the Pharmacokinetics of Warfarin or Digoxin in Healthy Subjects
12 ClinicalTrials.gov (NCT03565458) Gemigliptin, Dapagliflozin, Empagliflozin DDI Study
13 ClinicalTrials.gov (NCT05521984) Targeting Pediatric Brain Tumors With Sodium Glucose Cotransporter 2 Inhibitors (SGLT2i)
14 ClinicalTrials.gov (NCT00859898) Study of Dapagliflozin in Combination With Metformin XR to Initiate the Treatment of Type 2 Diabetes
15 ClinicalTrials.gov (NCT00660907) Efficacy and Safety of Dapagliflozin in Combination With Metformin in Type 2 Diabetes Patients
16 Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Med. 2013 Feb 20;11:43.
17 ClinicalTrials.gov (NCT01068756) Effect of Rifampin on the Pharmacokinetics of Dapagliflozin in Healthy Subjects
18 ClinicalTrials.gov (NCT04724837) Zibotentan and Dapagliflozin for the Treatment of CKD (ZENITH-CKD Trial)
19 ClinicalTrials.gov (NCT05986136) Activation of Autophagy and Suppression of Apoptosis by Dapagliflozin Attenuates Inflammatory Bowel Disease
20 ClinicalTrials.gov (NCT02313220) Exploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight
21 ClinicalTrials.gov (NCT05792540) Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depressive Disorders
22 ClinicalTrials.gov (NCT05938712) The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients
23 ClinicalTrials.gov (NCT05776043) Empagliflozin and Dapagliflozin in Patients Hospitalized for Acute Decompensated Heart Failure
24 ClinicalTrials.gov (NCT04255238) A Study to Evaluate the Efficacy and Safety of Dual add-on Therapy With Gemigliptin 50 mg and Dapagliflozin 10 mg Added to Metformin Who Have Inadequate Glycemic Control on Metformin Alone
25 ClinicalTrials.gov (NCT03762850) A Study of the Effect and Safety of Sparsentan in the Treatment of Patients With IgA Nephropathy
26 ClinicalTrials.gov (NCT01606007) Safety and Efficacy of Combination Saxagliptin & Dapagliflozin Added to Metformin to Treat Subjects With Type 2 Diabetes
27 ClinicalTrials.gov (NCT03074630) Dapagliflozin and Cholesterol Metabolism in Type 2 Diabetes (DM2)
28 ClinicalTrials.gov (NCT05443932) Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients
29 ClinicalTrials.gov (NCT02475070) Vildagliptin Versus Dapagliflozin on Glucagon
30 ClinicalTrials.gov (NCT03089333) Effects of SGLT2 Inhibitor on Hemodynamic Parameters in Resistant Hypertensive Subjects
31 ClinicalTrials.gov (NCT02973477) Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients With Type 2 Diabetes (T2D)
32 ClinicalTrials.gov (NCT02719132) Effect of DapagliFLOzin on Quality of Life in Patients With Type 2 Diabetes in a Real Clinical PrActice