Details of the Drug Combinations

General Information of This Drug (ID: DM2CUS0)

Drug Name
F901318   DM2CUS0
Synonyms
Olorofim; F-901318; UNII-T34SH2H9HI; T34SH2H9HI; 1928707-56-5; 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide; CHEMBL4297609; SCHEMBL17767345; BCP25872; BDBM50526857; DB15245; SB19827; F901318; F 901318; Olorofim; HY-104029; CS-0025660; Q27896127; CN1C(=C(C=C1C)C1=CC=CC=C1)C(C(=O)NC1=CC=C(C=C1)N1CCN(CC1)C1=NC=C(C=N1)F)=O; 1H-Pyrrole-2-acetamide, N-(4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)phenyl)-1,5-dimethyl-alpha-oxo-3-phenyl-; 2-(1,5-Dimethyl-3-phenyl-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxo-acetamide
Indication
Disease Entry ICD 11 Status REF
Fungal infection 1F29-1F2F Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
F901318 + Cyclosporin A DCZKJWP Cyclosporin A Invasive Aspergillosis [2]
F901318 + Caspofungin DC1OFN0 Caspofungin Pulmonary Aspergillosis - Invasive [3]
F901318 + Posaconazole DC5K5SB Posaconazole Invasive Aspergillosis [2]
F901318 + Pantoprazole DCEO4FI Pantoprazole Invasive Aspergillosis [2]
F901318 + Fluconazole DCNQDSK Fluconazole Invasive Aspergillosis [4]
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References

1 ClinicalTrials.gov (NCT03583164) Evaluate F901318 Treatment of Invasive Fungal Infections in Patients Lacking Treatment Options (FORMULA-OLS). U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT03095547) Drug/Drug Interactions With F901318
3 ClinicalTrials.gov (NCT02856178) Study on Safety and Pharmacokinetics of Intravenous F901318 for Fungal Prophylaxis in AML Patients
4 ClinicalTrials.gov (NCT02730442) Study of Potential for Interaction of Fluconazole With F901318