Details of the Drug Combinations

General Information of This Drug (ID: DM2Q50G)

Drug Name

Belnacasan DM2Q50G

Synonyms

Second generation ICE inhibitors, Vertex; VRT-043198; VRT-43198; VX-765; VX-765)

Indication

Disease Entry	ICD 11	Status	REF
Epilepsy	8A60-8A68	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Belnacasan + Marizomib	DCSKXRX	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Belnacasan + Idarubicin	DCXPORN	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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References

1	Pralnacasan, an inhibitor of interleukin-1beta converting enzyme, reduces joint damage in two murine models of osteoarthritis. Osteoarthritis Cartilage. 2003 Oct;11(10):738-46.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.