Details of the Drug Combinations

General Information of This Drug (ID: DM3NUMH)

Drug Name

Aripiprazole DM3NUMH

Synonyms

129722-12-9; Abilify; Abilitat; Abilify Discmelt; OPC-14597; Discmelt; Opc 14597; OPC 31; OPC-31; 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril; UNII-82VFR53I78; C23H27Cl2N3O2; HSDB 7320; 7-(4-(4-(2,3-DICHLOROPHENYL)PIPERAZIN-1-YL)BUTOXY)-3,4-DIHYDROQUINOLIN-2(1H)-ONE; CHEMBL1112; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone; CHEBI:31236; Abilify; Aripiprazol; Aripiprazolum; Aripirazole; Arpizol; Asprito; Pripiprazole; Aripiprazole [USAN]; Otsuka brand of aripiprazole; OPC 14597; ALKS-9070; Abilify (TN); BMS-337039; Bristol-Myers Squibb brand of aripiprazole; Discmelt (TN); KS-1030; S06-0010; Aripiprazole (JAN/USAN/INN); 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone; 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril; 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one; 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one; ALKS9070/ALKS9072; Aripiprazole/escitalopram fixed-dose combination

Indication

Disease Entry	ICD 11	Status	REF
Bipolar I disorder	N.A.	Approved	[1]
Erythropoietic porphyrias	5C58.12	Approved	[2]
Schizoaffective disorder	6A21	Approved	[1]
Schizophrenia	6A20	Approved	[3]
Major depressive disorder	6A70.3	Phase 3	[4]
Bipolar disorder	6A60	Application submitted	[5]
Autism	N.A.	Investigative	[1]
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Therapeutic Class

Antipsychotic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

10 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aripiprazole + Olanzapine	DC09CAJ	Olanzapine	Depression	[6]
Aripiprazole + Escitalopram	DCB2N18	Escitalopram	Major Depressive Disorder (MDD)	[7]
Aripiprazole + Cycloserine	DCM2GF4	Cycloserine	Autistic Disorder	[8]
Aripiprazole + Paliperidone	DCWOISJ	Paliperidone	Immunoassay	[9]
Quetiapine + Aripiprazole	DCXCB60	Quetiapine	Schizophrenia	[10]
Quetiapine + Aripiprazole	DCR2A8B	Quetiapine	Schizophrenia	[11]
Aripiprazole + Bupropion	DCFRTWC	Bupropion	Major Depressive Disorder	[12]
Aripiprazole + Modafinil	DCKZC2D	Modafinil	Schizophrenia	[13]
Aripiprazole + Paliperidone	DCSA8GZ	Paliperidone	Schizophrenia	[14]
Simvastatin + Aripiprazole	DCWS36N	Simvastatin	Schizophrenia	[15]
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References

1	Aripiprazole FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 34).
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034267)
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	ClinicalTrials.gov (NCT01057329) Therapeutic Drug Monitoring in Child and Adolescent Psychiatry
7	ClinicalTrials.gov (NCT01123707) To Assess the Safety and Tolerability of an Oral Aripiprazole/Escitalopram Combination Therapy in Participants With Major Depressive Disorder (MDD)
8	ClinicalTrials.gov (NCT00198107) Evaluating the Effectiveness of Aripiprazole and D-Cycloserine to Treat Symptoms Associated With Autism
9	ClinicalTrials.gov (NCT02634463) Whole Blood and Plasma Sample Collection for the Development of Antipsychotic Immunoassays From Participants Taking Aripiprazole, Olanzapine, Paliperidone, or Risperidone
10	ClinicalTrials.gov (NCT01164059) Clinical Effectiveness of Newer Antipsychotics in Comparison With Conventional Antipsychotics in Schizophrenia
11	ClinicalTrials.gov (NCT01129674) A Long-Term, Open-Label, Study on Schizophrenia
12	ClinicalTrials.gov (NCT01942187) A Comparison of Medication Augmentation and PST in the Treatment of Depression in Older Adults
13	ClinicalTrials.gov (NCT01913327) Antipsychotic Effects on Brain Function in Schizophrenia
14	ClinicalTrials.gov (NCT06060886) Multidisciplinary Design to Optimize Schizophrenia Treatment Based on Multi-omics Data and Systems Biology Analysis
15	ClinicalTrials.gov (NCT00802100) Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia