Details of the Drug Combinations

General Information of This Drug (ID: DM4BDON)

• Drug Name: Methylprednisolone (DM4BDON)
• Synonyms: Depo-medrol; M-predrol; Medrol; Medrol Acetate

Indication

Acute adrenal insufficiency; ICD 11: N.A.; Status: Approved [1]; Acute asthma; ICD 11: CA23; Status: Approved [1]; Addison disease; ICD 11: 5A74.0; Status: Approved [1]; Allergic rhinitis; ICD 11: CA08.0; Status: Approved [1]; Angioedema; ICD 11: 4A00.15; Status: Approved [1]; Aspiration pneumonitis; ICD 11: N.A.; Status: Approved [1]; Autoimmune haemolytic anaemia; ICD 11: 3A20; Status: Approved [1]; Bursitis; ICD 11: N.A.; Status: Approved [1]; Cerebral edema; ICD 11: 8D60.1; Status: Approved [1]; Chronic graft versus host disease; ICD 11: N.A.; Status: Approved [1]; Congenital adrenal hyperplasia; ICD 11: 5A71.01; Status: Approved [1]; Crohn disease; ICD 11: DD70; Status: Approved [1]; Dermatitis herpetiformis; ICD 11: EB44; Status: Approved [1]; Diamond-Blackfan anemia; ICD 11: N.A.; Status: Approved [1]; Disorder of orbital region; ICD 11: N.A.; Status: Approved [1]; Epicondylitis; ICD 11: N.A.; Status: Approved [1]; Erythema multiforme; ICD 11: N.A.; Status: Approved [1]; Exanthem; ICD 11: N.A.; Status: Approved [1]; Fever; ICD 11: MG26; Status: Approved [1]; Granuloma annulare; ICD 11: N.A.; Status: Approved [1]; Inflammatory bowel disease; ICD 11: DD72; Status: Approved [1]; Ischemia-reperfusion injury; ICD 11: DB98.B; Status: Approved [1]; Leukemia; ICD 11: N.A.; Status: Approved [1]; Lupus nephritis; ICD 11: 4A40.0Y; Status: Approved [1]; Microscopic polyangiitis; ICD 11: N.A.; Status: Approved [1]; Miliary tuberculosis; ICD 11: N.A.; Status: Approved [1]; Multiple sclerosis; ICD 11: 8A40; Status: Approved [1]; Mycosis fungoides; ICD 11: 2B01; Status: Approved [1]; Myeloproliferative neoplasm; ICD 11: 2A20; Status: Approved [1]; Pneumocystis pneumonia; ICD 11: CA40.20; Status: Approved [1]; Primary cutaneous T-cell lymphoma; ICD 11: N.A.; Status: Approved [1]; Psoriasis; ICD 11: EA90; Status: Approved [1]; Psoriatic arthritis; ICD 11: FA21; Status: Approved [1]; Rheumatic heart disease; ICD 11: N.A.; Status: Approved [1]; Rheumatoid arthritis; ICD 11: FA20; Status: Approved [2]; Sarcoidosis; ICD 11: 4B20.5; Status: Approved [1]; Seasonal allergic rhinitis; ICD 11: CA08.01; Status: Approved [1]; Serum sickness; ICD 11: N.A.; Status: Approved [1]; Severe asthma; ICD 11: CA23; Status: Approved [1]; Skin disease; ICD 11: EA00-EM0Z; Status: Approved [1]; Solid tumour/cancer; ICD 11: 2A00-2F9Z; Status: Approved [2]; Systemic lupus erythematosus; ICD 11: 4A40.0; Status: Approved [1]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Phase 3 [3]; Acquired thrombocytopenia; ICD 11: N.A.; Status: Investigative [1]; Asthma; ICD 11: CA23; Status: Investigative [1]; Beta-thalassemia major; ICD 11: N.A.; Status: Investigative [1]; Classic Hodgkin lymphoma; ICD 11: N.A.; Status: Investigative [1]; Follicular lymphoma; ICD 11: 2A80; Status: Investigative [1]; Perennial allergic rhinitis; ICD 11: CA08.03; Status: Investigative [1]; Spinal cord injury; ICD 11: ND51.2; Status: Investigative [4]; Synovitis; ICD 11: N.A.; Status: Investigative [1]; Trichinellosis; ICD 11: N.A.; Status: Investigative [1]

• Therapeutic Class: Anticancer Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

42 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Esomeprazole + Methylprednisolone	DC1WOD0	Esomeprazole	Thyroid-associated Ophthalmopathy	[5]
Levothyroxine + Methylprednisolone	DCBGKQH	Levothyroxine	Brain Death	[6]
Lidocaine + Methylprednisolone	DC4ZXLO	Lidocaine	Biceps Tendonitis	[7]
Methylprednisolone + Azathioprine	DCZ0EWR	Azathioprine	IgA Nephropathy	[8]
Methylprednisolone + Prednisolone	DC7RCGW	Prednisolone	Immune Reconstitution Inflammatory Syndrome	[9]
Methylprednisolone + Prednisone	DCDDCQB	Prednisone	IgA Nephropathy	[8]
Methylprednisolone + Etomidate	DCM66AY	Etomidate	Adrenocortical Deficiency	[10]
Methylprednisolone + Azithromycin	DCQJ9NF	Azithromycin	Idiopathic Pulmonary Fibrosis	[11]
Methylprednisolone + Solumedrol	DCBFEXT	Solumedrol	Normal Physiology	[12]
Ruxolitinib + Methylprednisolone	DCNWTS3	Ruxolitinib	Intestinal GVHD	[13]
Temozolomide + Methylprednisolone	DCUFTB3	Temozolomide	Lymphoma	[14]
VX-509 + Methylprednisolone	DC7TUNS	VX-509	Drug Interactions	[15]
Atorvastatin + Methylprednisolone	DC2QMO2	Atorvastatin	Thyroid Associated Ophthalmopathy	[16]
Carfilzomib + Methylprednisolone	DCQLZ6O	Carfilzomib	Multiple Myeloma	[17]
Cyclophosphamide + Methylprednisolone	DCAOIHS	Cyclophosphamide	Fanconi Anemia	[18]
Cyclophosphamide + Methylprednisolone	DCBAHA8	Cyclophosphamide	Kidney Transplantation	[19]
Cyclophosphamide + Methylprednisolone	DCECI3I	Cyclophosphamide	Lymphoproliferative Disorder	[20]
Diphenhydramine + Methylprednisolone	DC8ZV0Z	Diphenhydramine	Graft Rejection	[21]
Lidocaine + Methylprednisolone	DCHZT3E	Lidocaine	Knee Joint Osteoarthrosis	[22]
Methylprednisolone + Prednisolone	DCCH6H1	Prednisolone	Cerebral Radiation Necrosis	[23]
Mycophenolate mofetil + Methylprednisolone	DCZDO0K	Mycophenolate mofetil	Familial Lipoprotein Lipase Deficiency	[24]
Mycophenolate mofetil + Methylprednisolone	DCIZMOT	Mycophenolate mofetil	Primary Renal Allograft Candidate	[25]
Ruxolitinib + Methylprednisolone	DCTELEY	Ruxolitinib	Acute GVHD	[26]
Cyclophosphamide + Methylprednisolone	DCHN54L	Cyclophosphamide	Glomerulonephritis, Membranous	[27]
Dexamethasone + Methylprednisolone	DCCHIYQ	Dexamethasone	Dysphasia	[28]
Everolimus + Methylprednisolone	DCISY1G	Everolimus	Transplant; Failure, Kidney	[29]
Heparin + Methylprednisolone	DC1BSGA	Heparin	Covid19	[30]
Heparin + Methylprednisolone	DCLYRM7	Heparin	COVID-19	[31]
Methylprednisolone + Hydroxychloroquine	DC3P733	Hydroxychloroquine	Thrombocytopenia	[32]
Mycophenolate mofetil + Methylprednisolone	DCHYTTM	Mycophenolate mofetil	Kidney Transplantation	[33]
Mycophenolate mofetil + Methylprednisolone	DC81D3X	Mycophenolate mofetil	Systemic Lupus Erythematosus, Lupus Nephritis	[34]
Budesonide + Methylprednisolone	DCOT1P1	Budesonide	Chronic Obstructive Pulmonary Disease	[35]
Cyclophosphamide + Methylprednisolone	DC576S1	Cyclophosphamide	Lupus Nephritis	[36]
Everolimus + Methylprednisolone	DCN0M87	Everolimus	Renal Transplanted Recipients	[37]
Everolimus + Methylprednisolone	DCX9QPS	Everolimus	Drug Interaction Potentiation	[38]
Methylprednisolone + Mycophenolic acid	DCGH2QK	Mycophenolic acid	Renal Transplanted Recipients	[37]
Methylprednisolone + Ropivacaine	DCUT7TO	Ropivacaine	Osteoarthritis	[39]
Metoclopramide + Methylprednisolone	DCCETDO	Metoclopramide	Migraine	[40]
Mycophenolate mofetil + Methylprednisolone	DCH7O7V	Mycophenolate mofetil	Drug Interaction Potentiation	[38]
Mycophenolate mofetil + Methylprednisolone	DC9852W	Mycophenolate mofetil	Kidney Transplantation	[41]
Mycophenolate mofetil + Methylprednisolone	DC9C9H9	Mycophenolate mofetil	Renal Transplantation	[42]
Mycophenolate mofetil + Methylprednisolone	DCOUY5O	Mycophenolate mofetil	Liver Transplantation	[43]

References

• [1] Methylprednisolone FDA Label
• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [3] ClinicalTrials.gov (NCT04341038) Clinical Trial to Evaluate Methylprednisolone Pulses and Tacrolimus in Patients With COVID-19 Lung Injury
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7088).
• [5] ClinicalTrials.gov (NCT01579539) The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy
• [6] ClinicalTrials.gov (NCT04528797) Thyroid and Adrenocortical Hormone Replacement in Organ Donors
• [7] ClinicalTrials.gov (NCT02591953) Prospective Clinical Analysis of Ultrasound-guided Biceps Corticosteroid Injections
• [8] ClinicalTrials.gov (NCT01392833) Steroids and Azathioprine in Advanced IgAN
• [9] ClinicalTrials.gov (NCT01211665) Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS)
• [10] ClinicalTrials.gov (NCT01792037) Single Dose of Etomidate and Adrenal Cortex
• [11] ClinicalTrials.gov (NCT05842681) Azithromycin in the Management of Patients With Acute Exacerbation of Idiopathic Pulmonary Fibrosis
• [12] ClinicalTrials.gov (NCT02798523) Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids
• [13] ClinicalTrials.gov (NCT04269850) Fecal Microbiota Transplantation With Ruxolitinib and Steroids as an Upfront Treatment of Severe Acute Intestinal GVHD
• [14] ClinicalTrials.gov (NCT00248534) Rituximab, Temozolomide, and Methylprednisolone in Treating Patients With Recurrent Primary CNS Non-Hodgkin's Lymphoma
• [15] ClinicalTrials.gov (NCT01886209) Phase 1 PK Interaction Study Between VX-509 and Prednisone or Methylprednisolone in Healthy Male Subjects
• [16] ClinicalTrials.gov (NCT03110848) Effects of Atorvastatin in Graves' Orbitopathy (GO)
• [17] ClinicalTrials.gov (NCT02294357) Weekly 70 mg/m2 Carfilzomib for Multiple Myeloma Patients Refractory to 27 mg/m2 Carfilzomib
• [18] ClinicalTrials.gov (NCT00258427) Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia
• [19] ClinicalTrials.gov (NCT00801632) Combined Kidney and Bone Marrow Transplantation to Prevent Kidney Transplant Rejection
• [20] ClinicalTrials.gov (NCT00066469) Cyclophosphamide, Rituximab, and Either Prednisone or Methylprednisolone in Treating Patients With Lymphoproliferative Disease After Solid Organ Transplantation
• [21] ClinicalTrials.gov (NCT00771875) Randomized Trial for Mixed Acute Rejection
• [22] ClinicalTrials.gov (NCT02253966) Preoperative Intraarticular Injection of Methylprednisolone in Patients Scheduled for Total Knee-arthroplasty
• [23] ClinicalTrials.gov (NCT03067753) Monosialoganglioside Ganglioside in Cerebral Radiation Necrosis
• [24] ClinicalTrials.gov (NCT00891306) Efficacy and Safety of Human Lipoprotein Lipase (LPL)[S447X] Expressed by an Adeno-Associated Viral Vector in LPL-deficient Subjects
• [25] ClinicalTrials.gov (NCT01856257) Open-Label Phase 2 Trial of a Steroid-Free, CNI-Free, Belatacept-Based Immunosuppressive Regimen
• [26] ClinicalTrials.gov (NCT03701698) Ruxolitinib and Steroid as First Line Therapy for Acute GVHD
• [27] ClinicalTrials.gov (NCT03018535) Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy
• [28] ClinicalTrials.gov (NCT03308084) Use of Local Intraoperative Steroid in MIS TLIF
• [29] ClinicalTrials.gov (NCT01680861) Tacrolimus/Everolimus Versus Tacrolimus/Enteric-Coated Mycophenolate Sodium
• [30] ClinicalTrials.gov (NCT04528888) Steroids and Unfractionated Heparin in Critically Ill Patients With Pneumonia From COVID-19 Infection
• [31] ClinicalTrials.gov (NCT04485429) Efficacy Assessment of Methylprednisolone and Heparin in Patients With COVID-19 Pneumonia
• [32] ClinicalTrials.gov (NCT02444728) Cyclophosphamide and Hydroxychloroquine for Thrombocytopenia in SLE
• [33] ClinicalTrials.gov (NCT00481819) A Study to Compare the Efficacy and Safety of FK506MR vs Prograf in Patients Undergoing Kidney Transplantation
• [34] ClinicalTrials.gov (NCT01773616) Trial of Rituximab and Mycophenolate Mofetil Without Oral Steroids for Lupus Nephritis
• [35] ClinicalTrials.gov (NCT01865500) Two Different Dosages of Nebulized Steroid Versus Parenteral Steroid in the Management of COPD Exacerbations
• [36] ClinicalTrials.gov (NCT02645565) Comparison of Low Dose Versus High Dose Cyclophosphamide as Induction Therapy in the Treatment of Lupus Nephritis
• [37] ClinicalTrials.gov (NCT00371826) SOCRATES: Steroid or Cyclosporine Removal After Transplantation Using Everolimus
• [38] ClinicalTrials.gov (NCT02077556) Effect of Everolimus on the Pharmacokinetics of Tacrolimus in Renal Transplant Patients
• [39] ClinicalTrials.gov (NCT02576249) Corticosteroid/Ropivacaine Versus Corticosteroid/Saline Injections for Knee Osteoarthritis
• [40] ClinicalTrials.gov (NCT02847494) Corticosteroids for Acute Migraine in the Emergency Department
• [41] ClinicalTrials.gov (NCT00885820) Benefit of Early Protocol Biopsy and Treatment of Subclinical Rejection
• [42] ClinicalTrials.gov (NCT00650468) A Study to Compare Early Steroid Withdrawal and Long-Term Steroid Maintenance Therapy in Kidney Transplant Patients
• [43] ClinicalTrials.gov (NCT00545402) A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Liver Transplant Patients.