Details of the Drug Combinations

General Information of This Drug (ID: DM4DMBT)

• Drug Name: Chlorthalidone (DM4DMBT)
• Synonyms: Chlorothalidone; Chlorphthalidolone; Chlorphthalidone; Chlortalidone; Chlortalidonum; Chlorthalidon; Clortalidona; Clortalidone; Famolin; Higroton; Hygroton; Igroton; Isoren; Natriuran; Oradil; Oxodolin; Oxodoline; Phthalamodine; Phthalamudine; Renon; Saluretin; Thalitone; Urolin; Zambesil; Clortalidone [DCIT]; Racemic chlorthalidone; G 33182; Chlortalidonum [INN-Latin]; Chlorthalidone (USP); Clortalidona [INN-Spanish]; G-33182; Hydro-Long; Hygroton (TN); Oksodolin (oxodolin); Thalitone (TN); Chlortalidone (JAN/INN); Chlorthalidone [USAN:INN:BAN]; (+-)-Chlorthalidone; (+-)-Hygroton; 1-Keto-3-(3'-sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline; 1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline; 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide; 2-Chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide; 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide; 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide; 3-(4'-Chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine; 3-Hydroxy-3-(4-chloro-3-sulfamylphenyl)phthalimidine

Indication

Edema; ICD 11: MG29; Status: Approved [1]; Hypertension; ICD 11: BA00-BA04; Status: Approved [1]; High blood pressure; ICD 11: BA00; Status: Investigative [2]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

12 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Chlorthalidone + Amlodipine	DCPZY7H	Amlodipine	Hypertension	[3]
Chlorthalidone + Amlodipine	DCFUKT5	Amlodipine	Hypertension	[4]
Chlorthalidone + Hydrochlorothiazide	DCZ1Z5S	Hydrochlorothiazide	Kidney Stones	[5]
Chlorthalidone + Amlodipine	DC5AOCT	Amlodipine	Hypertension	[6]
Chlorthalidone + Telmisartan	DCV9A0T	Telmisartan	Hypertension	[7]
Chlorthalidone + Indapamide	DCASCDK	Indapamide	Kidney Stone	[8]
Chlorthalidone + Spironolactone	DC0X15D	Spironolactone	Renal Insufficiency	[9]
Chlorthalidone + Bumetanide	DCF4P7S	Bumetanide	Renal Insufficiency, Chronic	[10]
Chlorthalidone + Amiloride	DCVQPUE	Amiloride	Hypertension	[11]
Chlorthalidone + Lisinopril	DCM2S0Z	Lisinopril	Hypertension	[12]
Chlorthalidone + Lisinopril	DCADO04	Lisinopril	Hypertension	[12]
Chlorthalidone + Furosemide	DCMNTO5	Furosemide	End Stage Renal Disease on Dialysis	[13]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7147).
• [2] Chlorthalidone FDA Label
• [3] ClinicalTrials.gov (NCT02121041) Ambulatory vs Office BP Management Usual Care for Diagnosing and Managing Hypertension: A Pilot Study
• [4] ClinicalTrials.gov (NCT05976438) Skin Sodium and Salt Sensitivity of Blood Pressure
• [5] ClinicalTrials.gov (NCT02711670) Night Time Use of Thiazide Diuretics for Improved Reduction in Stone Risk in Stone Formers With Elevated Urine Calcium
• [6] ClinicalTrials.gov (NCT02152969) Drug-drug Interaction Study (Telmisartan, Amlodipine, Chlorthalidone)
• [7] ClinicalTrials.gov (NCT01806363) Pharmacokinetic Interactions and Safety Study of Telmisartan and Chlorthalidone
• [8] ClinicalTrials.gov (NCT06111885) Indapamide and Chlorthalidone to Reduce Urine Supersaturation for Kidney Stone Prevention
• [9] ClinicalTrials.gov (NCT05222191) Spironolactone in CKD Enabled by Chlorthalidone: PILOT
• [10] ClinicalTrials.gov (NCT03923933) Chlortalidone and Bumetanide in Advanced Chronic Kidney Disease: HEBE-CKD Trial
• [11] ClinicalTrials.gov (NCT03928145) Efficacy of Chlorthalidone and Hydrochlorothiazide Combined With Amiloride on Blood Pressure in Primary Hypertension.
• [12] ClinicalTrials.gov (NCT02847338) Comparison of Optimal Hypertension Regimens
• [13] ClinicalTrials.gov (NCT05915286) Diuretic Use in Hemodialysis Patients With Residual Renal Function