Details of the Drug Combinations

General Information of This Drug (ID: DM4G60V)

Drug Name

AC265347 DM4G60V

Synonyms

AC-265347; AC 265347

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
AC265347 + Diltiazem	DC7JKZG	Diltiazem	DD2 (Cell Line: DD2)	[2]
AC265347 + Chloroquine	DC1KIZ3	Chloroquine	DD2 (Cell Line: DD2)	[2]
AC265347 + Piperaquine	DCKVV8I	Piperaquine	DD2 (Cell Line: DD2)	[2]
AC265347 + Diltiazem	DCM53W5	Diltiazem	Hepatoblastoma (Cell Line: HB3)	[3]
Artemisinin + AC265347	DCS6XOU	Artemisinin	DD2 (Cell Line: DD2)	[2]
------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3947).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.